Abstract: Cervical cancer is one of the most common female malignancies，resulted from both environmental factors and genetic variants. Recent research revealed that polymorphisms of MTHFR may have a correlation with increased cervical cancer susceptibility. A proposed mechanism for the role of MTHFR polymorphisms in carcinogenesis involves down-regulation of folate enzyme activities and interaction with the other factors such as folate level，human papillomaviruses infection，alcohol，smoking and the interaction of the proto-oncogene，which leaded to the abnormal patterns of DNA synthesis and methylation，influenced the individual susceptibility to cervical cancer, and played a completely different role in different countries and ethnic groups. MTHFR polymorphisms may also have a relationship with tumor prognosis by affecting the susceptibility to the chemotherapy and drug toxicity，however，whether it was associated with cervical cancer prognosis remained uncertain. This review concluded the relationship between MTHFR polymorphisms and cervical cancer in host susceptibility，epidemiology and prognosis as followed.

Key words: Tetrahydrofolate dehydrogenase, Polymorphism, genetic, Uterine cervical neoplasms, Disease susceptibility