Journal of International Obstetrics and Gynecology

Journal of International Obstetrics and Gynecology ›› 2009, Vol. 36 ›› Issue (5): 373-376.

• 综述 • Previous Articles     Next Articles

The Progression on the Relationship Between AngⅡ, AT1R and Gynecological Oncology

ZHANG Ming-na;QU Peng-peng   

  1. Tianjin Medical University, Tianjin 300070, China （ZHANG Ming-na）; Tianjin Central Gynecology & Obstetric Hospital, Tianjin 300052, China（QU Peng-peng）
  • Received:2008-12-26 Revised:1900-01-01 Published:2009-10-15 Online:2009-10-15

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Abstract: AngiotensinⅡ（AngⅡ） is the main active component of the Renin-Angiotensin-aldosterone
system（RAS） and plays an important role in human blood pressure and liquid-electrolyte balance. Recently years, studies indicated that, RAS does not only exist in the blood circulation but also in some malignant tumor tissues, and in region tissues, and AngⅡparticipates tumor genesis, development and angiogenesis through binding to the AT1R. As a result, blocking AngⅡ or Angiotensin Ⅱ type 1 receptor （AT1R） may be a new target for tumor therapy. This article intents to summarize the progression on the relationship between AngⅡ, AT1R and gynecological oncology.

Key words: AngiotensinⅡ, Angiotensin Ⅱ type 1 receptor, Gynecological oncology