Table of Content

15 October 2009, Volume 36 Issue 5
   Next Issue
---
述评
综述
论著
标准与指南


For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

述评

Select

Evaluation on Neoadjuvant Chemotherapy in Advanced Ovarian Carcinoma QU Quan-xin;MI Ruo-ran 2009, 36 (5):  341-342.  Abstract ( 1991 )   PDF (185KB) ( 4875 )   Ovarian cancer, especially for advanced ovarian cancer, is a kind of common gynecologic malignant tumor with higher rate of relapse and death. It is the main reason that bulk unremovable tumor after cytoreductive surgery result in multidrug resistance, relapse and bad prognosis. It has been testified for nearly thirty years that neoadjuvant chemotherapy could reduce tumor volume, improve optimal cytoreduction rate and prognosis. However improved optimal cytoreduction rate failed to prolong the median lifetime. Therefore, we should evaluate objectively for the efficacy of neoadjuvant chemotherapy in advanced ovarian cancer based on the clinical meta-analysis. Related Articles | Metrics

综述

Select

Obese and Polycystic Ovary Syndrome in Adolescents SUN Jing;WANG Yong;WU Xiao-ke 2009, 36 (5):  343-347.  Abstract ( 2482 )   PDF (255KB) ( 5006 )   Polycystic ovary syndrome （PCOS） is a common disorder among reproductive-aged women. Recent research has elucidated that as the prevalence of pediatric obesity escalates, the morbidity of polycystic ovary syndrome in adolescent females is also increasing. Obesity contributes to the pathophysiology of polycystic ovary syndrome by increasing free insulin concentrations. Hyperandrogenism in PCOS can also increase visceral fat. Obesity can increase the morbidities of associated metabolic and cardiovascular dieases including insulin resistance （IR）, dyslipidemia, hypertension and subclinical cardiovascular disease such as atherosclerosis. Early identification of adolescent polycystic ovary syndrome will help to correct and block the endocrine disorders, as well as the complications in the near future timely. Related Articles | Metrics

Select

Some New Thoughts About the Pathophysiology of Polycystic Ovary Syndrome WANG Na-mei;LI wei;WU Xiao-ke;HOU Li-hui 2009, 36 (5):  348-351.  Abstract ( 2389 )   PDF (232KB) ( 4802 )   Polycystic ovary syndrome（PCOS） is a common endocrine disorder, characterized by chronic anovulation and hyperandrogenism. The primary clinical manifestations of PCOS are infertility, hirsutism, chronic anovulation, menstrual irregularity, and polycystic ovaries. Excessive androgen production plays a critical role in the pathogenesis of PCOS, and the proposed mechanisms responsible for increased ovarian androgen include heightened theca cell responsiveness to gonadotropin stimulation, increased pituitary secretion of luteinizing hormone, and hyperinsulinemia. Insulin resistance and obesity may make the syndrome more severe. The interaction of androgen, insulin, gonadotropins, and obesity contributes to the reproductive phenotype of PCOS. Related Articles | Metrics

Select

The Action of Chemokines in the Pathogenesis of Endometriosis WU Ya-ling;HAO Min 2009, 36 (5):  352-355.  Abstract ( 3100 )   PDF (268KB) ( 4977 )   Endometriosis is one of the common gynecological diseases defined by the presence, growth, and invasion of endometrial tissue outside the uterine cavity. It is mainly associated with chronic pelvic pain, dysmenorrhe and infertility and its prevalence increases year by year. Although many hypotheses have been proposed, the etiology of the disease remains an enigma. Inflammation and dysimmunity are important pathologic basis of endometriosis, Attachment-aggression-angiogenesis is the basic step of occurrence and development of EMs. Recent studies have suggested that the chemokines are involved in cultivation of endometriosis in the course of chemokine, adhesion, invasion, angiogenesis and cell proliferation and apoptosis and other important links. In this article, we make the review on the roles of chemotactic factor in occurrence and development of EMs. Related Articles | Metrics

Select

Apoptosis and Endometriosis LIANG Cheng;WU Rui-jin;LIN Jun 2009, 36 (5):  356-359.  Abstract ( 2208 )   PDF (222KB) ( 4857 )   The aetiology and pathogenesis of endometriosis remain obscure. Endometriosis is a commom gynecological disease, but it has some malignant behavors, such as hyperplasia, invasion, metastasis and recurrence. It is still a difficult problem for the preventation and treatment of endometriosis. Apoptosis is a distinctive form of programmed cell death, it plays a critical role in maintaining tissue homeostasis and represents a normal function to eliminate excess or dysfunctional cells. Accumulated evidence suggests that abnormal apoptosis can promote the occurrence and development of endometriosis. This study is a current review of the literature focused on the apoptosis pathways, expression of apoptosis in normal endometrium and the alterations in regulation of apoptosis in eutopic and ectopic endometrium from women with endometriosis. The role of apoptosis in the treatment of endometriosis is reviewed to link the basic research findings with clinical applications. Related Articles | Metrics

Select

The Research Progress of Several Chinese and Western Medicine on Endometrial Receptivity ZHU Hong;WANG Fang;LI Bing 2009, 36 (5):  360-363.  Abstract ( 1933 )   PDF (243KB) ( 4827 )   Endometrial receptivity is an integrated state of endometrium acceptable embryo implantation, which is closely related to embryo implantation rate and pregnancy rate. In recent years, with the development of assisted reproductive technology, the application of ovulation induction drugs, diagnosis and treatment of infertility have increased to a new level, the key point is to improve embryo implantation rate and pregnancy rate. Controlled ovarian hyperstimulation drugs will affect the growth of the endometrium, and change the endometrial receptivity. In this paper, we summarize of several Chinese and western medicine on endometrial receptivity, with a view to provide reference to improve the success rate of assisted reproductive technology. Related Articles | Metrics

Select

The Progression About Fitz-Hugh-Curtis Syndrome Study JIN Cui-ping;SHANG Yu-min 2009, 36 (5):  364-366.  Abstract ( 1776 )   PDF (230KB) ( 4964 )   Fitz-Hugh-Curtis is a rare syndrome characterised by perihepatitis following pelvic inflammatory disease. It is mainly apparant at hepatic capsular without liver parenchyma damage in sufferers with chronic pelvic inflammatory disease. The pathogenic bacteria mainly include diplococcus gonorrhoeae and chlamydia. The clinical manifestation of Fitz-Hugh-Curtis is chronic abdominal pain, infertility, ectopic pregnancy and so on. It will be diagnosed and differentially diagnosed with abdominal CT, lab testing and laparoscopy, and will be cured with effective antibiotic and laparoscopic surgery. Here we review the cause and onset of disease, clinical feature, complication, diagnosis, therapy and the significance on Fitz-Hugh-Curtis syndrome. Related Articles | Metrics

Select

The Cyr61 and Gynecological Tumor PENG Li-xiu;ZHOU Chang-ju 2009, 36 (5):  367-370.  Abstract ( 2455 )   PDF (226KB) ( 4714 )   Cysteine-rich 61（Cyr61） is a representive member in the connective tissue growth factor family. It has multimode construction that possess the function of inducing angiogenesis and promoting cell adhesion and metastasize and multidrug resistance. Cyr61 plays an essential role in the pathology of the endometrial cancer, cervical cancer, ovary cancer, uterus myoma and endometriosis. Related Articles | Metrics

Select

The Research of RNA Interference in the Treatment of Gynecological Malignant Tumor FENG Kun;ZHOU Huai-jun 2009, 36 (5):  371-372.  Abstract ( 1776 )   PDF (181KB) ( 4791 )   RNA interference （RNAi） is a post-transportational gene silencing induced by introduction of double-stranded RNA. With the deepening study of RNAi technology, its mechanism is being clarified gradually. RNAi technology is also becoming more perfect and mature, and has been widely used in many research areas, such as functional genome, microbiology and regulatory mechanism of gene expression. And a breakthrough has been made in the field of tumor therapy. So it has opened a new effective way in tumor area. This article will provide a review on the application of RNAi technology on gynecologic malignant. Related Articles | Metrics

Select

The Progression on the Relationship Between AngⅡ, AT1R and Gynecological Oncology ZHANG Ming-na;QU Peng-peng 2009, 36 (5):  373-376.  Abstract ( 1714 )   PDF (216KB) ( 4728 )   AngiotensinⅡ（AngⅡ） is the main active component of the Renin-Angiotensin-aldosterone system（RAS） and plays an important role in human blood pressure and liquid-electrolyte balance. Recently years, studies indicated that, RAS does not only exist in the blood circulation but also in some malignant tumor tissues, and in region tissues, and AngⅡparticipates tumor genesis, development and angiogenesis through binding to the AT1R. As a result, blocking AngⅡ or Angiotensin Ⅱ type 1 receptor （AT1R） may be a new target for tumor therapy. This article intents to summarize the progression on the relationship between AngⅡ, AT1R and gynecological oncology. Related Articles | Metrics

Select

Paclitaxel Chemothrepy for Cervical Cancer LIU Hui-ling;MI Ruo-ran 2009, 36 (5):  377-379.  Abstract ( 2045 )   PDF (197KB) ( 4723 )   The anti-tumour agent paclitaxel has proved to be effective for the treatment of patients with solid tumor, and recently many results also indicate it’s clinically highly effective in patients with cervical cancer. Paclitaxel chemotherapy for cervical cancer is reviewed in three directions including monochemotherapy, and two or three drugs combination chemotherapy. The regimen of paclitaxel（T） combined with cisplatin（P） or carboplatin（C） has proved highly effective and safe, showing it is superior to monotherapy or three drugs combination therapy, especially in neoadjuvant chemotherapy. Compared with TP, TC demonstrates easiness of administration for improved renal toxicity of carboplatin. TP or TC combining with radiotherapy shows significant effect. Weekly paclitaxel has similar response rate and less adverse reaction versus the standard 3-weekly paclitaxel. Paclitaxel chemothrepy would be more popular for cervical cancer patients. Related Articles | Metrics

Select

Clinical Researches of Neoadjuvant Chemotherapy for Cervical Cancer HUANG Qing-hua;LI Li 2009, 36 (5):  380-383.  Abstract ( 2213 )   PDF (215KB) ( 4730 )   Neoadjuvant chemotherapy refers to systemic chemotherapy given to patients before local treatment （surgery or radiotherapy）. Scholars from both China and abroad have explored the modality therapy for neoadjuvant chemotherapy combined with surgery or radiotherapy on cervical cancer over the last two decades and they have learned certain experiences in this area. But the status of this therapy is not clear yet and there is no consensus on how to choose its appropriate chemotherapy protocol. The latest therapeutic progress of neoadjuvant chemotherapy, the effect of various regimens, and their development trends now are being reviewed. Related Articles | Metrics

Select

The Progress on the Transport of Fetal and Mature WU Dong-ling;MA Qing-liang;HU Ke 2009, 36 (5):  384-386.  Abstract ( 2316 )   PDF (198KB) ( 4779 )   Thyroid hormone （TH） is essential for the normal development and metabolism of different tissues, and also is also vital for fetal development and pregnancy. There is evidence that maternal thyroid hormones can cross the human placenta and act to modulate fetal endocrine system development before the onset of the fetus’s own thyroid hormone production. The transport of thyroid hormones has now been shown to require specific transporter proteins, and as yet few data are available to define the important transporting proteins in the human placenta. To date, members of the organic anion- transporting polypeptide, L-type amino acid, and of the monocarboxylate transporter families, sodium iodide symporter, have been identified as thyroid hormone transporters. However, further research is necessary to determine the role of these and other proteins in placental transport of thyroid hormone, and to investigate how modulations of their function could affect fetal pathologies such as intrauterine growth restriction, abortion, implantation failure and embryonal, fetal death. Related Articles | Metrics

Select

Toll Like Receptor and Gene Polymorphisms and Preterm Birth DUAN Li-jun;ZENG Wei-yue 2009, 36 (5):  387-390.  Abstract ( 2328 )   PDF (226KB) ( 4792 )   Toll like receptors （TLRs） have been identified as transmembrane signal transduction proteins in recent years. As a group of pattern recognition receptors （PRRs）, TLRs are important regulators of the innate immune response based on their ability to recognize and respond to pathogen-associated molecular patterns expressed by microbes. Genetic polymorphisms affect the susceptibility of individuals and single nucleotide polymorphisms of TLR genes, which are associated with the inflammatory responses and susceptibility to infectious diseases. With the development of reproductive immunology, relevant studies of TLRs and their gene polymorphism and preterm birth have been gradually carried out, providing new concepts and ideas for diagnosis, treatment and prognosis of premature cases. Related Articles | Metrics

Select

Recent Advances in Predictors and Their Screen Time of Preterm Delivery DONG Wei;ZHANG Jian-ying;HAN Yu-huan 2009, 36 (5):  391-393.  Abstract ( 2645 )   PDF (216KB) ( 4782 )   Preterm delivery is one of the main causes for perinatal complications and death. Many literatures focus on preterm prediction study and evaluate every predictor. The predictors include cervical length and the size of some of fetal organs measured by ultrasound; the level of fFN, IGFBP-1, IL investigated in cervicovaginal fluid, serum relaxin, CRP and HbA1c in mother’s blood, MMP-8, MCP-1 and ITAC in amniotic fluid which correlated with infection. The purpose of these studies is to find some more reliable factors to predict preterm delivery and improve the perinatal quality. Related Articles | Metrics

Select

Risk Factors for Ectopic Pregnancy XU Hong;LIN Jun;WU Rui-jin 2009, 36 (5):  394-397.  Abstract ( 2388 )   PDF (226KB) ( 4936 )   Ectopic pregnancy（EP） remains the leading cause of maternal mortality in the first trimester of pregnancy. The incidence of EP has been rising for several decades, so recognition of it′s risk factors could help to facilitate early diagnosis, treatment and prevention. In the researches of our country and abroad, the associated risk factors for EP mainly include pelvic inflammatory diseases （PID）, previous abdominal surgeries, cigarette smoking, previous EP, a history of infertility, the use of assisted reproductive technique, the failure of contraception, abortion, and the the older maternal age et al. And while PID, previous tubal surgery and cigarette smoking are considerd to be the most common three risk factors. Yet, EP is always accompanied by one or more risk factors. Related Articles | Metrics

Select

Soluble Endoglin and Preeclampsia HE Yao;DONG Min-yue 2009, 36 (5):  398-400.  Abstract ( 3146 )   PDF (190KB) ( 4930 )   Soluble endoglin（sEng, sCD105）is a 65 ku serum protein and its aminoacid sequence corresponds to N- terminal soluble structure of full-length endoglin. It may be shed by membrane type matrix metalloprotease-1（MT1-MMP）. The serum level of sEng was elevated in preeclamptic individuals and correlated with disease severity and gestational weeks. Besides, it was elevated 6-10 weeks before the onset of preeclampsia. sEng blocks transforming growth factor （TGF）-β1- mediated formation of human umbilical vein endothelial tubes in vitro and induces vascular permeability and hypertension in pregnant rats in vivo. The research of the effect of sEng in preeclampsia is one of the recent progresses in the pathogenesis of preeclampsia. Related Articles | Metrics

Select

Advances in Research on Cardiac Function in Pregnancy Evaluated With New Echocardiographic Techniques JIA Li;GAO Xiao-jun 2009, 36 (5):  401-404.  Abstract ( 2375 )   PDF (229KB) ( 4736 )   Echocardiography is an important means of evaluating cardiac function in pregnancy now. Compared with conventional methods, various kinds of new echocardiographic techniques, such as AQ, Tei-index, TDI, SRI, QTVI and RT-3DE are used synthetically to offer more abundant prognostic indexes of maternal cardiac function for the clinical decision in normal pregnancy and pregnancy-induced hypertension syndrome. They have a significant clinical and social meaning for the survival rates of pregnant women and fetus. Related Articles | Metrics

Select

Research Advancement of ABCA3 MA Xiao-jing;XU Yong-ping 2009, 36 (5):  405-407.  Abstract ( 2509 )   PDF (199KB) ( 4945 )   The ABCA3 gene, of the ABCA subclass of ATP binding cassette （ABC） transporters, is expressed exclusively in lung and is located on chromosome 16p13.3. It spans over 80 000 nucleotide bases and is transcribed into an approximately 6 500-bp mRNA, which directs the synthesis of a 1704-amino-acid protein of 190 kDa size. ABCA3 mediates the translocation of a wide variety of substrates, including lipids, across cellular membranes. It does not only cause multidrug resistance but also causes a neonatal respiratory distress syndrome and increase susceptibility to milder forms of interstitial lung disease. ABCA3 variants might result deficiency or reduction of ABCA3 protein expression. Sometimes the protein expressed in the correct amount and location, but does not function properly. These conditions may influence the process and transportion of surfactant proteins B and C, break the pulmonary surfactant phospholipid homeostasis, and induce to the neonatal lung diseases. Related Articles | Metrics

论著

Select

The Study of the Nuclear Red Blood Cells′ Rich by Interfering Membrane Ionic Channels Selectively CHENG Ning;ZHANG Li-na;LIU Fang;XU Xiang-hong;Ya-na 2009, 36 (5):  408-410.  Abstract ( 3157 )   PDF (527KB) ( 4930 )   Objective: To investigate the effectiveness of the Nuclear Red Blood Cells ′ rich by effecting membrane ionic channels-Anion Exchanger and Na+/K+/2Cl- Co-transporter in umbilical cord blood. Methods: Make the optimal interfering condition from RBCs on the umbilical cord blood，the rate of cells′ enrichment by discontinuous density centrifugation on different densities were determined by Flow Cytometry（FCM）. Results: The average purity of NRBCs enrichment in the umbilical cord blood could take from 2.4% to 9.7% （u=3.19, P<0.05） by interfering, which means to increase about 4 times of enrichment of NRBC. Conclusions: Both Verapamil and Furosemide could promote the rate of NRBC′enrichment about 4 times. Related Articles | Metrics

标准与指南

Select

Interpretation of the 2009 FIGO New Staging for Carcinoma of the Vulvar, Cervix, Endometrium LIN Zhong-qiu;WU Zhu-na 2009, 36 (5):  411-412.  Abstract ( 1892 )   PDF (154KB) ( 5086 )   Related Articles | Metrics