Abstract: RNA interference （RNAi） is a post-transportational gene silencing induced by introduction of
double-stranded RNA. With the deepening study of RNAi technology, its mechanism is being clarified gradually. RNAi technology is also becoming more perfect and mature, and has been widely used in many research areas, such as functional genome, microbiology and regulatory mechanism of gene expression. And a breakthrough has been made in the field of tumor therapy. So it has opened a new effective way in tumor area. This article will provide a review on the application of RNAi technology on gynecologic malignant.

Key words: RNA interference, Cervical cancer, Ovarian cancer, Endometrial cancer