Abstract: Polycystic ovary syndrome（PCOS） is a common endocrine disorder, characterized by chronic anovulation and hyperandrogenism. The primary clinical manifestations of PCOS are infertility, hirsutism, chronic anovulation, menstrual irregularity, and polycystic ovaries. Excessive androgen production plays a critical role in the pathogenesis of PCOS, and the proposed mechanisms responsible for increased ovarian androgen include heightened theca cell responsiveness to gonadotropin stimulation, increased pituitary secretion of luteinizing hormone, and hyperinsulinemia. Insulin resistance and obesity may make the syndrome more severe. The interaction of androgen, insulin, gonadotropins, and obesity contributes to the reproductive phenotype of PCOS.

Key words: Polycystic ovary, Androgen, Anovulation, Hirsutism, Luteinizing hormone