Research Progress of Embryonic Development and the Origin of Polycystic Ovary Syndrome

doi:10.12280/gjfckx.20220695

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, closely related to clinical manifestations such as metabolic disorders and ovulation disorders, the pathogenesis of which remains unclear. A growing number of researches have proposed that the embryonic developmental period is a critical stage in the origin of PCOS disease. Numerous genetic genes for PCOS have functions involved in hormone synthesis as well as regulation of the glucose and lipid metabolic pathways. The expression patterns and epigenetic regulation of genes during different gestational periods may also be relevant to fetal ovarian development. Altered maternal hormone status, exposure to environmental endocrine disruptors, unhealthy lifestyle and metabolic disorders during pregnancy may increase the risk of PCOS by interfering with the function of the hypothalamus-pituitary-ovary axis and varying the expression levels of genes, inducing endocrine disorders such as hyperandrogenemia, insulin resistance and disturbances in follicular development in the offspring. This article reviews the susceptibility genes and epigenetic regulation of PCOS, and to explore the mechanism of intrauterine environmental alterations inducing reprogramming of embryonic development, which will provide new perspectives for future studies on the pathogenesis and clinical treatment of PCOS.

Key words: Polycystic ovary syndrome, Embryonic development, Genetic predisposition to disease, Endocrine disruptors, Life style

MAO Jing-xia, PAN Yong-chao, WU Rui-jin. Research Progress of Embryonic Development and the Origin of Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2023, 50(2): 132-137.

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