Abstract: Soluble endoglin（sEng, sCD105）is a 65 ku serum protein and its aminoacid sequence corresponds to N-
terminal soluble structure of full-length endoglin. It may be shed by membrane type matrix metalloprotease-1（MT1-MMP）. The
serum level of sEng was elevated in preeclamptic individuals and correlated with disease severity and gestational weeks.
Besides, it was elevated 6-10 weeks before the onset of preeclampsia. sEng blocks transforming growth factor （TGF）-β1-
mediated formation of human umbilical vein endothelial tubes in vitro and induces vascular permeability and hypertension in
pregnant rats in vivo. The research of the effect of sEng in preeclampsia is one of the recent progresses in the pathogenesis
of preeclampsia.

Key words: Endoglin, Preeclampsia, Pregnancy