Abstract: Objective：To evaluate the relationship between tumor necrosis factor-α（TNF-α） 308G/A polymorphism and cervical cancer risk. Methods：By searching PubMed，Embase，Cochrane Library，China Academic Journals Full-text database（1979-2014.1），VIP Database（1989—2014.1），Wanfang database（2000—2014.1），we collect the study on TNF-α 308G/A polymorphism and cervical cancer susceptibility. According to the inclusion and exclusion criteria to select test and evaluate the quality，and then extract the valid data. Results：We included 16 case-control study. Meta-analysis showed that the total population，TNF-α 308G/A polymorphism is associated with cervical cancer susceptibility[A vs. G：OR=1.242，95%CI（1.044-1.478），P=0.014]. Subgroup analysis also showed as follow，Asian populations：the genotypes were not increase the risk of cervical cancer（P＞0.05）；Caucasian populations：[A vs. G：OR=1.299，95%CI（1.052-1.603），P=0.015；AA vs. GG：OR=1.627，95%CI（1.044-2.534），P=0.031；AA vs.（GA+GG）：OR=1.616，95%CI（1.033-2.527），P=0.036]；African populations：[GA vs. GG：OR=1.533，95% CI（1.023-2.297），P=0.039；GA vs.（AA+GG）：OR=1.531，95%CI（1.024-2.291），P=0.038]. By Bgger′s and Egger′s test to determine publication bias，the results showed that there have publication bias [A vs. G（P=0.029，0.030）]. Conclusions：The results of the current research of Meta-analysis showed that the TNF-α 308G/A gene may increase the risk of cervical cancer，but still need a large sample of high-quality researches further confirmed.

Key words: Uterine cervical neoplasms, Tumor necrosis factor-alpha, Genotype, Polymorphism, genetic, Meta-analysis