Abstract: Hormone replacement therapy （HRT） can alleviate postmenopausal women′ menopausal symptoms，prevent osteoporosis and reduce fractures with a consensus，but its influence on breast cancer，cardiovascular disease and other chronic diseases is still controversial. Using estrogen alone may not increase the risk of breast cancer，while combining estrogen with progesterone may increase breast cancer′s risk. Different breast disease patients may suffer different risks of breast cancer after HRT，the relationship between Chinese women HRT and breast cancer are uncertain. Benefits exceed risks when applying HRT on women who have indications close to post menopause，different types and occupy pathways of HRT may result in different breast cancer risks. Summarize the relationship between HRT and breast cancer as well as HRT applications in patients with different breast disease.

Key words: Hormone replacement therapy, Breast neoplasms, Menopause, Breast diseases, Therapy