Abstract: Neoadjuvant chemotherapy（NACT） as one way of the comprehensive therapy mainly used in the case for
stageⅠB2 toⅡA disease. Many researchers believed neoadjuvant chemotherapy before surgical can shrink the tumor volume，improve the operability and resection rate. At the same time， it lows the postoperative complications. And the effectiveness is more than 80% including 9%-18% proved completely relived by pathology.However，NACT may delay the patients treatment who can not respond to it and lead to suffering and waste. In recent years，foreign and domestic investigators are trying to find out some molecular markers and hope to predict the efficacy by certain molecular marker and find out the non-responder as early as possible. It can improve the prognosis and survival rate. This paper will summarize the research on prediction efficacy molecular marker in advanced cervical cancer.

Key words: Uterine cervical neoplasms, Chemotherapy, adjuvant, Biological markers, DNA repair, Cell proliferation