Abstract: Objective： To evaluate the clinical effect and safety of hyperthermia combined with radiotherapy and chemotherapy（HRCT） for advanced cervical cancer. Methods：The database such as， The Cochrane library， PubMed， EMBASE， CBM，CNKI，VIP and WANFANG Data were searched up to May of 2013， and other sources as supplied were also retrieved to collect all the relevant randomized controlled trials （RCTs） on comparing HCRT with non-HCRT .The quality of the included trials was assessed according to the Cochrane Hand book 5.1 for systematic review and the features of this study as well. Meta-analyses were conducted by using RevMan 5.2 software. Results：A total of sixteen RCTs involving 1 295 patients were included. The results of Meta-analysis showed that ①HCRT group′s short-term efficacy（complete remission rate，local control rate）were higher than HRT group，CRT group and RT group. HCRT group′s efficiency rate were higher than CRT group and RT group.HCRT group′s long-term efficacy：one year disease-free survival rate was higher than CRT group and HRT group. In terms of two-year and five-year survival rate, there were no significant differences compared with non-HCRT. In terms of three-year survival rate，there were no significant differences compared with CRT group and RT group，but was higher than HRT group.② Safety evaluation：the incidence rates of bladder reaction， rectum reaction and dry dermatitis were similar among the HCRT group and the non-HCRT group .There were no significant differences in HCRT compared with non-HCRT. Considering the incidence rates of gastrointestinal reaction，marrow suppression， HCRT group was higher than RT and HRT group. There were significant differences between HCRT group and RT and HRT group . Conclusions：Compared with other therapies，HCRT tends to improve the clinical efficacy，but this result needs to be proved by more clinical trails. HCRT is superior to the routine radio-chemotherapy in efficacy，but the relevant evidence for proving its long-term efficacy and safety is still required.

Key words: Uterine cervical neoplasms, Caicinoma, Hyperthermia, Radiotherapy, Antineoplastic combined chemotherapy protocols, Meta-analysis