Abstract: Ectopic pregnancy（EP） is a frequent surgical abdomen of obstetrics and gynecology，the incidence of which is rising in the recent twenty years. The developing of diagnostic techniques can reduce the rate of misdiagnosis and missed diagnosis， in order to create favorable conditions for better reserve fertility and conservative treatment of EP. The most common methods of early diagnosis of ectopic pregnancy are using ultrasound with serial measurements of human chorionic gonadotropin（β-HCG）. However， these cannot find the embryo as early as gestational 4-5weeks，not only for EP， but also for intrauterine pregnnacy. In recent years， research of diagnostic of serum markers for ectopic pregnancy have great progression， and this review will give a summarize， including human chorionic gonadotropin， progesterone， vascular endothelial grow factor，PAPP-A and activin-inhibin.

Key words: Ectopic pregnancy, Early diagnosis, Serum markers, Activin-inhibin