Journal of International Obstetrics and Gynecology

Journal of International Obstetrics and Gynecology ›› 2012, Vol. 39 ›› Issue (6): 616-619.

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Relationship Between Suppressor of Cytokine Signaling-3 and Cell Migration and Invasion

TU Fei-xia，LIN Jun   

  1. Department of Obstetrics and Gynecology，Women's Hospital，School of Medicine，Zhejiang University，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15

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Abstract: Suppressor of cytokine signaling-3（SOCS-3），a common inhibitory molecule regulating many signaling pathways like JAK/STAT（Janus kinase/signal transducer and activator of transcription） and MAPK（mitogen-activated protein kinases），plays an important role in equating physical activities of cells when exposed to cytokines，growth factor and hormones. Cells capabilities of migration and invasion，which participate in tumor metastasis and many physiological processes，are wildly regulated by SOCS-3.

Key words: Suppressor of cytokine signaling proteins, Cell movement, Signaling pathway, Invasion