代谢组学在宫颈癌筛查和早期诊断中的应用

doi:10.12280/gjfckx.20210797

摘要/Abstract

摘要：

宫颈癌是最常见的妇科恶性肿瘤,也是一种可防可治的恶性肿瘤,筛查和早期诊断对降低宫颈癌发病率和死亡率意义重大。宫颈癌发生发展过程中,往往会出现代谢物种类和数量的变化,涉及葡萄糖代谢、谷氨酰胺代谢和脂质代谢等。因此代谢组学在探索宫颈癌发生发展机制和新的筛查诊断手段方面有较大潜力。通过对血液、尿液、组织和细胞等生物样本进行代谢物分析,寻找与宫颈癌变密切相关的代谢物变化,将有望获得兼具高敏感度和高特异度且简便、易被患者接受的新筛查诊断方法。综述代谢组学在宫颈癌筛查和早期诊断中的应用。

关键词: 宫颈肿瘤, 代谢组学, 脂类代谢, 氨基酸, 肿瘤微环境, 早期诊断

Abstract:

Cervical cancer is the most common gynecological cancer, which is preventable and treatable. Improved screening and early detection played important role in reducing the incidence and mortality of cervical cancer. During the development of cervical cancer, there are often alterations in the type and quantity of metabolites, involving glucose metabolism, glutamine metabolism and lipid metabolism. Therefore, metabolomics has great potential in exploring mechanisms of cervical cancer initiation and development as well as new methods of screening and early detection. Through metabolite analysis of biological samples such as blood, urine, tissues and cells, we can find changes in metabolites closely related to cervical cancer and establish new screening and diagnostic methods with high sensitivity and specificity as well as convenience and good acceptability. The aim of this review is to explore the possible application of metabolomics in screening and early detection of cervical cancer.

Key words: Uterine cervical neoplasms, Metabolomics, Lipid metabolism, Amino acids, Tumor microenvironment, Early diagnosis

葛彦君, 张雨晨, 王新焘, 诸海燕. 代谢组学在宫颈癌筛查和早期诊断中的应用[J]. 国际妇产科学杂志, 2022, 49(3): 302-306.

GE Yan-jun, ZHANG Yu-chen, WANG Xin-tao, ZHU Hai-yan. The Role of Metabolomics in Cervical Cancer Screening and Early Diagnosis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(3): 302-306.

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