慢性子宫内膜炎发病机制及诊疗进展

doi:10.12280/gjfckx.20220626

摘要/Abstract

摘要：

子宫内膜容受性的建立是胚胎成功着床的必备条件，随着辅助生殖技术的不断完善，子宫内膜异常已成为影响辅助生殖技术过程中胚胎着床的最主要因素。持续的子宫内膜片状出血、粘连、间质密度增加、子宫内膜间质异常浆细胞浸润被称为慢性子宫内膜炎。慢性子宫内膜炎可通过影响子宫内膜容受性造成不良妊娠结局，并与子宫内膜息肉、子宫内膜异位症和宫腔粘连等疾病的发生有关，接受抗生素治疗可显著改善辅助生殖技术妊娠结局。综述慢性子宫内膜炎的病因、诊断、治疗及对辅助生殖技术领域影响的研究进展。

关键词: 慢性子宫内膜炎, 多配体蛋白聚糖1, 胚胎植入, 抗菌药, 生殖技术, 辅助, 子宫内膜容受性

Abstract:

Establishment of endometrial receptivity is a important condition for successful embryo implantation. With the assisted reproductive technology getting better, endometrial abnormalities have become the most important factor of embryo implantation. Chronic endometritis (CE) is characterized by persistent mucosal stromal edema, focal or diffuse hyperemia and stromal plasmacyte infiltration. CE could cause adverse pregnancy outcomes by affecting endometrial receptivity. By the way, CE may be associated with the occurrence of endometrial polyps, endometriosis and intrauterine adhesions. The treatment of antibiotics could significantly improve the clinical outcomes of assisted reproductive technology. This article reviews the etiology, diagnosis and treatment of CE, and summarize the research progress under the influence of CE on assisted reproductive technology as well.

Key words: Chronic endometritis, Syndecan-1, Embryo implantation, Anti-bacterial agents, Reproductive techniques, assisted, Endometrial receptivity

王修竹, 陈学梅, 刘雪梅. 慢性子宫内膜炎发病机制及诊疗进展[J]. 国际妇产科学杂志, 2023, 50(1): 102-108.

WANG Xiu-zhu, CHEN Xue-mei, LIU Xue-mei. Research Progress in Pathogenesis and Diagnosis of Chronic Endometritis[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 102-108.

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