自噬反应在慢性子宫内膜炎发病中的潜在作用

doi:10.12280/gjfckx.20210984

国际妇产科学杂志 ›› 2022, Vol. 49 ›› Issue (3): 246-249.doi: 10.12280/gjfckx.20210984

• 普通妇科疾病及相关研究:综述 • 上一篇下一篇

自噬反应在慢性子宫内膜炎发病中的潜在作用

王兴, 杨如玉, 司徒晓华, 梁炎春()

510089 广东,中山大学中山医学院（王兴,司徒晓华）;中山大学附属第一医院妇科（杨如玉,梁炎春）

收稿日期:2021-10-25 出版日期:2022-06-15 发布日期:2022-06-23
基金资助:
国家自然科学基金(82071618);广东省科技创新战略专项资金(2021A1515012615);广东大学生科技创新培育专项资金(pdjh2021b0020);广东大学生科技创新培育专项资金(pdjh2020b0015);中山大学大学生创新训练计划(20201219);中山大学大学生创新训练计划(20201220);中山大学大学生创新训练计划(202110558079);2021年中山大学附属第一医院柯麟新星人才计划(R08013)

Potential Role of Autophagy in the Pathogenesis of Chronic Endometritis

WANG Xing, YANG Ru-yu, SITU Xiao-hua, LIANG Yan-chun()

Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510089, China (WANG Xing, SITU Xiao-hua);Department of Gynecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China (YANG Ru-yu, LIANG Yan-chun)

Received:2021-10-25 Published:2022-06-15 Online:2022-06-23

摘要/Abstract

摘要：

慢性子宫内膜炎（chronic endometritis,CE）可引起不孕症、复发性流产和反复植入失败等不良生殖预后,其发病机制尚未阐明。CE患者的子宫内膜组织中存在异常的自噬反应,提示自噬在CE发病中发挥重要作用。研究发现,CE的发生与巨噬细胞分布、极化异常以及NOD样受体蛋白3（NOD-like receptor protein 3,NLRP3）炎症小体的异常激活密切相关。而且,巨噬细胞极化以及NLRP3炎症小体的组装和激活均受自噬反应调控。因此,自噬反应可能通过调节巨噬细胞极化影响NLRP3炎症小体激活,从而参与CE的发生。上述观点为CE发病机制提供了新的认识,也为其治疗提供了潜在的新靶点。

关键词: 自噬, 巨噬细胞, NLR家族,热蛋白结构域包含蛋白3, 子宫内膜炎, 慢性子宫内膜炎

Abstract:

Chronic endometritis (CE) can lead to infertility, recurrent pregnancy loss and recurrent implantation failure. The specific pathogenesis mechanism of CE remains unknown. Abnormal autophagy was proved in the endometrium of patients with CE, indicating that autophagy plays an important role in the development of CE. Researches have confirmed that the development of CE is related with abnormal distribution and polarization of macrophages, as well as abnormal activation of NOD-like receptor protein 3 (NLRP3) inflammasome, both of which are modulated by autophagy. Thus, we propose that autophagy may activate NLRP3 inflammasome by regulating macrophage polarization, thereby leading to the occurrence of CE. This review illustrates a new insight for the pathogenesis of CE and provides new potential targets for the treatment of CE.

Key words: Autophagy, Macrophages, NLR family,pyrin domain-containing 3 protein, Endometritis, Chronic endometritis

王兴, 杨如玉, 司徒晓华, 梁炎春. 自噬反应在慢性子宫内膜炎发病中的潜在作用[J]. 国际妇产科学杂志, 2022, 49(3): 246-249.

WANG Xing, YANG Ru-yu, SITU Xiao-hua, LIANG Yan-chun. Potential Role of Autophagy in the Pathogenesis of Chronic Endometritis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(3): 246-249.

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自噬反应在慢性子宫内膜炎发病中的潜在作用

Potential Role of Autophagy in the Pathogenesis of Chronic Endometritis

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