近红外/吲哚菁绿荧光成像技术在妇科手术中的应用进展

doi:10.12280/gjfckx.20220950

摘要/Abstract

摘要：

近红外荧光成像（near-infrared fluorescence imaging，NIRF）技术目前已广泛应用于临床实践中，现阶段临床常用的近红外荧光染剂为吲哚菁绿（indocyanine green，ICG）。近红外光与ICG相结合形成的近红外/ICG荧光成像技术在各学科领域均已广泛开展，可用于妇科恶性肿瘤中转移淋巴结的检测以及术中导航。就盆腔深部浸润型子宫内膜异位症而言，应用近红外/ICG荧光成像技术可以更完整地清除病灶，尤其对于肠道子宫内膜异位症，可显著减少肠瘘发生率。该技术亦可用于术中输尿管显影，不仅可减少既往常用保护输尿管的方法（如术前放置输尿管支架）引起的并发症，也可减少医源性输尿管损伤的发生率。就近红外/ICG荧光成像技术的原理和优势、在妇科手术中的发展现状和临床应用，以及该技术的局限性和应用前景予以综述。

关键词: 近红外荧光成像, 放射性示踪剂, 宫颈肿瘤, 子宫内膜肿瘤, 子宫内膜异位症

Abstract:

Near-infrared fluorescence imaging (NIRF) technology has been widely used in clinical practice, the commonly used near-infrared fluorescent dye in clinical practice at present is indocyanine green (ICG). The near-infrared/ICG fluorescence imaging technology, which combines near-infrared light with ICG, has been widely developed in various fields, and can be used for the detection of metastatic lymph nodes in gynecological malignant tumors and intraoperative navigation. As for the pelvic deep-infiltrating endometriosis, the application of near-infrared/ICG fluorescence imaging technology can more completely clear the lesions, especially for intestinal endometriosis, which can significantly reduce the incidence of intestinal fistula. It can also be used for intraoperative ureteral imaging, which not only reduces the complications caused by the usual methods of ureteral protection (such as preoperative placement of ureteral stents), but also reduces the incidence of iatrogenic ureteral injury. The principle and advantages of near-infrared/ICG fluorescence imaging technology, its development status and clinical application in gynecological surgery, as well as the limitations and application prospects of this technology are reviewed.

Key words: Near-infrared fluorescence imaging, Radioactive tracers, Uterine cervical neoplasms, Endometrial neoplasms, Endometriosis

罗炜虹, 翟瑞芳. 近红外/吲哚菁绿荧光成像技术在妇科手术中的应用进展[J]. 国际妇产科学杂志, 2023, 50(3): 241-245.

LUO Wei-hong, ZHAI Rui-fang. Application Progress of Near-Infrared/Indocyanine Green Fluorescence Imaging in Gynecological Surgery[J]. Journal of International Obstetrics and Gynecology, 2023, 50(3): 241-245.

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