脂肪间充质干细胞外泌体在妇科疾病的应用及进展

doi:10.12280/gjfckx.20230908

摘要/Abstract

摘要：

随着干细胞研究的发展，脂肪间充质干细胞（adipose derived mesenchymal stem cell，ADSC）和脂肪间充质干细胞外泌体（adipose derived mesenchymal stem cell exosome，ADSC-Exo）成为妇科领域的研究热点。ADSC是一类来源于脂肪组织的间充质干细胞，与其他间充质干细胞一样具有较高的增殖能力和多向分化潜能，ADSC-Exo还可通过释放的细胞外囊泡传递各种生物活性分子，如微小RNA、蛋白质和细胞因子，对目标细胞发挥一定的调节作用。ADSC-Exo在妇科领域的应用日益受到关注。有研究表明，ADSC-Exo可以促进子宫内膜的再生和修复，为宫腔粘连和不孕症的患者带来了希望。此外，一些研究提到ADSC-Exo在慢性子宫内膜炎、卵巢功能不全、多囊卵巢综合征和妇科恶性肿瘤等疾病的治疗中也具有一定的潜力。综述ADSC-Exo在妇科领域的应用及进展。

关键词: 间质干细胞, 外泌体, 生殖器疾病, 女（雌）性, 治疗, 脂肪间充质干细胞外泌体

Abstract:

With the development of stem cell research, adipose derived mesenchymal stem cell (ADSC) and adipose derived mesenchymal stem cell exosome (ADSC-Exo) have become a hot research topic in the field of gynecology. ADSC, a type of adipose-derived mesenchymal stem cells, has high proliferative capacity and multidirectional differentiation potential like other mesenchymal stem cells. ADSC-Exo can deliver a variety of biologically active molecules, such as microRNAs, proteins, and cytokines through released extracellular vesicles to play a certain regulatory role in the target cells. The application of ADSC-Exo in gynecology has also received increasing attention. Some studies have shown that ADSC-Exo can promote endometrial regeneration and repair, bringing hope to patients with intrauterine adhesion and infertility. In addition, some studies mentioned that ADSC-Exo also has potential in the treatment of chronic endometritis, ovarian insufficiency, polycystic ovary syndrome and gynecological malignancies. This paper reviews the application and advancements of ADSC-Exo in gynecology.

Key words: Mesenchymal stem cells, Exosomes, Genital diseases, female, Therapy, Adipose derived mesenchymal stem cell exosome

石丽娟, 于晓川, 王化丽. 脂肪间充质干细胞外泌体在妇科疾病的应用及进展[J]. 国际妇产科学杂志, 2024, 51(3): 274-278.

SHI Li-juan, YU Xiao-chuan, WANG Hua-li. Application and Progress of Adipose Derived Mesenchymal Stem Cell Exosomes in Gynecological Diseases[J]. Journal of International Obstetrics and Gynecology, 2024, 51(3): 274-278.

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