锶介导的妊娠期氧化应激调控机制及其对母婴健康的影响

doi:10.12280/gjfckx.20250538

摘要/Abstract

摘要：

锶是机体必需的微量元素之一，孕妇体内锶含量可能对妊娠结局产生一定影响，尤其是在胎儿生长发育和妊娠并发症方面。研究表明，孕妇体内锶含量异常可能通过干扰氧化还原稳态参与妊娠相关疾病的病理过程。氧化应激是子痫前期、妊娠期糖尿病及胎儿生长受限等疾病的发病机制之一。近年研究发现，锶可通过调控抗氧化酶活性、抑制脂质过氧化等途径参与氧化应激反应的调节，提示其在维持妊娠期氧化平衡中可能发挥一定作用。因此，维持孕妇体内适宜的锶水平，对于降低子痫前期、妊娠期糖尿病等妊娠并发症风险，促进胎儿正常生长发育，从而保障母婴健康具有潜在的重要意义。

关键词: 痕量元素, 锶, 氧化性应激, 妊娠结局, 妊娠并发症

Abstract:

Strontium is one of the essential trace elements in the human body. The strontium content in pregnancy women may have a certain impact on pregnancy outcomes, especially in terms of fetal growth and development and pregnancy-related complications. Research has shown that abnormal strontium content in pregnant women may participate in the pathological processes of pregnancy-related diseases by interfering with redox homeostasis. Oxidative stress is one of the pathogenic mechanisms of diseases such as pre-eclampsia, gestational diabetes mellitus, and fetal growth restriction. In recent years, studies have found that strontium can participate in the regulation of oxidative stress responses by regulating the activity of antioxidant enzymes and inhibiting lipid peroxidation, suggesting that it may play a certain role in maintaining oxidative balance during pregnancy. Therefore, maintaining an appropriate strontium level in pregnant women is potentially of great significance for reducing the risk of pregnancy complications such as pre-eclampsia and gestational diabetes mellitus, promoting normal fetal growth and development, and thus ensuring the health of both the mother and the infant.

Key words: Trace elements, Strontium, Oxidative stress, Pregnancy outcome, Pregnancy complications

段璞楚, 王小健, 张彦玲. 锶介导的妊娠期氧化应激调控机制及其对母婴健康的影响[J]. 国际妇产科学杂志, 2025, 52(5): 558-562.

DUAN Pu-chu, WANG Xiao-jian, ZHANG Yan-ling. Regulatory Mechanisms of Strontium Mediated Oxidative Stress during Pregnancy and Its Impacts on Maternal and Infant Health[J]. Journal of International Obstetrics and Gynecology, 2025, 52(5): 558-562.

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