国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (5): 367-370.

• 综述 • 上一篇    下一篇

富半胱氨酸61与妇科肿瘤

彭丽秀;周昌菊   

  1. 410013 长沙，中南大学湘雅三医院[彭丽秀(现在湖南省郴州市第一人民医中心医院，423000)、周昌菊]
  • 收稿日期:2008-11-28 修回日期:1900-01-01 出版日期:2009-10-15 发布日期:2009-10-15
  • 通讯作者: 周昌菊

The Cyr61 and Gynecological Tumor

PENG Li-xiu;ZHOU Chang-ju   

  1. The Third Xiangya Hospital of Central South University, Changsha 410013,China［PENG Li-xiu （now working at The Central Hospital of the First People’s Hospital of Chenzhou）, ZHOU Chang-ju］
  • Received:2008-11-28 Revised:1900-01-01 Published:2009-10-15 Online:2009-10-15
  • Contact: ZHOU Chang-ju

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摘要： 富半胱氨酸61（Cyr61）是结缔组织生长因子（CCN）家族中具有代表性的成员，其富含半胱氨酸残基的分泌性肝素连接蛋白具有多模组结构。具有诱导血管生成，促进细胞黏附、转移及诱导多药耐药形成等效用，在子宫内膜癌、宫颈癌、卵巢癌、子宫肌瘤及子宫内膜异位症的发生发展中起重要作用。

关键词: 富半胱氨酸61, 结缔组织生长因子, 肿瘤

Abstract: Cysteine-rich 61（Cyr61） is a representive member in the connective tissue growth factor family. It has multimode construction that possess the function of inducing angiogenesis and promoting cell adhesion and metastasize and multidrug resistance. Cyr61 plays an essential role in the pathology of the endometrial cancer, cervical cancer, ovary cancer, uterus myoma and endometriosis.

Key words: Cysteine-rich 61, Connective tissue growth factor, Tumor