国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (6): 417-419.

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内脏脂肪素与妊娠

华绍芳;韩玉环   

  1. 300211 天津医科大学第二医院产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-12-15 发布日期:2009-12-15

Visfatin and Pregnancy

HUA Shao-fang;HAN Yu-huan   

  1. Department of Obstetrics, the Second Hospital of TianJin Medical University, Tianjin 300211, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-12-15 Online:2009-12-15

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摘要： 内脏脂肪素（visfatin）主要是由内脏脂肪组织分泌的一种脂肪细胞因子，可以调节脂肪积累和外周组织对胰岛素的敏感性。妊娠妇女体脂分布的变化以及胎儿附属物对内脏脂肪素合成分泌的变化，可能参与了妊娠期生理性胰岛素抵抗的发生，并与临产发动有关。内脏脂肪素表达异常与胎儿生长受限、妊娠期高血压疾病以及妊娠期糖尿病等的发生存在一定相关性。妊娠妇女内脏脂肪素检测及其在妊娠并发症诊疗中的应用价值尚有广阔研究前景。

关键词: 内脏脂肪素, 妊娠, 胰岛素抵抗

Abstract:

Visfatin is a newly identified adipocytokine produced by visceral fat tissue. This protein plays an important role in adipose accumulation and may regulate the insulin sensitivity of many peripheral organs. During pregnancy, the variation of fat distribution and the existence of fetal appendage may affect visfatin production, which may be involved in physiological insulin-resistance and the start of labor. Abnormal secretion of visfatin is associated with fetal growth retardation, hypertensive and diabetic diseases during pregnancy. The detection of visfatin in pregnant women and its practical role in high risk pregnancy should be further studied.

Key words: Visfatin, Pregnancy, Insulin-resistence