国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (6): 420-423.

• 综述 • 上一篇    下一篇

绒毛膜羊膜炎的滋养细胞凋亡与感染性早产

周欣;孙丽洲   

  1. 210029 南京医科大学第一附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-12-15 发布日期:2009-12-15
  • 通讯作者: 孙丽洲

Apoptosis of Trophoblast Cells With Chorioamnionitis and Infection-related Preterm Labor

ZHOU Xin;SUN Li-zhou   

  1. Department of Obsterics and Gynecology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-12-15 Online:2009-12-15
  • Contact: SUN Li-zhou

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摘要： 早产是围生儿发病和死亡的主要原因。早产病因较多，其中由各种微生物引起的绒毛膜羊膜炎与感染性早产的发生发展关系密切，其发病机制尚未完全明确。研究发现，绒毛膜羊膜炎时胎盘局部微环境发生改变。其中如肿瘤坏死因子α（TNF-α）、γ干扰素（IFN-γ）等细胞因子及其他因子，如一氧化氮（NO）及其代谢产物的相关改变与滋养细胞凋亡有关，而后者又通过多种途径与感染性早产的发生有关。通过对绒毛膜羊膜炎时滋养细胞凋亡的研究有望为感染性早产的临床预防和治疗提供新的思路和方法。

关键词: 绒毛膜羊膜炎, 凋亡, 早产, 细胞因子

Abstract: Preterm labor is the leading cause of perinatal morbidity and mortality of pregnancies. The etiology of preterm labor and delivery is multiple, the onset of chorioamnionitis caused by a variety of microorganisms is closely associated with the development of infection-related preterm labor. However, the underlying pathogenesis mechanism is not yet completely clear. Recent study found that there are many changes in the local micro-environment when chorioamnionitis placental, in which, cytokines such as tumor necrosis factor-α（TNF-α）, γ-interferon（IFN-γ）, and other factors, like nitric oxide（NO）and its metabolites，whose related changes are associated with trophoblast cell apoptosis, while the apoptosis of trophoblast cells through a variety of ways, change the occurrence of infection-related preterm labor, By the time the study of trophoblast apoptosis is expected to offer new ideas and methods for the clinical prevention and treatment of prematurity when chorioamnionitis happen.

Key words: Chorioamnionitis, Apoptosis, Preterm labor, Cytokines