国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (6): 440-442.

• 综述 • 上一篇    下一篇

微小RNA与宫颈癌

张佳荣;李双弟;万小平   

  1. 200080 上海交通大学附属第一人民医院妇产科(张佳荣, 李双弟); 上海交通大学附属国际和平妇幼保健院(万小平)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-12-15 发布日期:2009-12-15

MicroRNA and Cervical Cancer

ZHANG Jia-rong;LI Shuang-di;WAN Xiao-ping   

  1. The First People’s Hospital Affiliated Shanghai Jiaotong University, Shanghai 200080, China（ZHANG Jia-rong, LI Shuang-di）；Shanghai International Peace Maternity and Child Health Hospital, Shanghai 200030, China（WAN Xiao-ping）
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-12-15 Online:2009-12-15

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摘要： 宫颈癌是最常见的恶性肿瘤之一，高危人乳头状瘤病毒（HPV）感染是宫颈癌发生的必要因素。微小RNA（miRNA）是一类内源性非编码的小RNA，参与了许多病毒致病和肿瘤发生过程。利用实验生物学及生物信息学方法对与肿瘤相关的miRNA进行研究是当前研究的热点。其中，在宫颈癌中目前已发现若干miRNA（如miR-21，-143，-146a，-199a等）的异常表达。综述miRNA与宫颈癌发生发展关系的研究。

关键词: 微小RNA, 宫颈癌, 人乳头瘤病毒, 肿瘤

Abstract: Cervical cancer is one of the most common malignant tumors,which is caused primarily by high risk human papilloma virus infection. MicroRNAs are endogenous noncoding small RNAs, which take part in many processes including virus infection and tumorigenesis. Great concern has been raised regarding cancer-related microRNAs recently. In cervical cancer, several microRNAs（miR-21, -143, -146a, -199a, et al） have been found to be de-expressed. Here we discuss the role of microRNAs in the development and progression of cervical cancer.

Key words: MicroRNA, Cervical cancer, Human papilloma virus, Tumor