国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (6): 454-457.

• 综述 • 上一篇    下一篇

β连环素在卵巢肿瘤中的研究进展

李俊;鹿欣   

  1. 200011 上海市复旦大学附属妇产科医院
  • 收稿日期:2009-01-05 修回日期:1900-01-01 出版日期:2009-12-15 发布日期:2009-12-15
  • 通讯作者: 鹿欣

New Discoveries on β-catenin in Ovarian Neoplasms

LI Jun;LU Xin   

  1. Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
  • Received:2009-01-05 Revised:1900-01-01 Published:2009-12-15 Online:2009-12-15
  • Contact: LU Xin

PDF (PC)

4653

被引次数

6

摘要： β连环素（β-catenin）主要参与Wnt信号通路和上皮钙黏蛋白（E-cadherin）介导的细胞间的黏附，其在多数肿瘤中存在异常表达。研究表明，Wnt/β-catenin信号通路的异常激活与卵巢肿瘤的发生密切相关。同时，E-cadherin/β-catenin复合体的改变直接参与卵巢肿瘤的侵袭转移。卵巢肿瘤动物模型的出现进一步证明β-catenin在卵巢肿瘤发生发展中的作用。对卵巢肿瘤中β-catenin的研究进展做文献综述。

关键词: β连环素, 卵巢肿瘤, 上皮钙黏蛋白, Wnt

Abstract: β-catenin is mainly involved in Wnt signaling pathway and E-cadherin-mediated cell-cell adhesion. Abberant β-catenin expression occurrs in most human malignancies. Recent studies demonstrated that deregulation of Wnt/β-catenin signaling pathway was related to the pathogenesis of ovarian neoplasms. Meanwhile, alteration of E-cadherin/β-catenin complex plays a significant role in the invasiveness and metastasis of ovarian cancer. Furthermore, the establishment of mouse models confirmed β-catenin′s role in the development of ovarian tumors. This review will summarize the new discoveries on β-catenin in ovarian neoplasms.

Key words: β-catenin, Ovarian neoplasms, E-cadherin, Wnt