国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (6): 458-461.

• 综述 • 上一篇    下一篇

卵巢癌早期诊断的血清肿瘤标志物研究进展

栾晓蕊;李卫平;狄文   

  1. 200001 上海交通大学医学院附属仁济医院妇产科
  • 收稿日期:2009-02-03 修回日期:1900-01-01 出版日期:2009-12-15 发布日期:2009-12-15
  • 通讯作者: 狄文

Advances on Serum Tumor Markers of Early Diagnosis of Ovarian Cancer

LUAN Xiao-rui;LI Wei-ping;DI Wen   

  1. Department of Obstetrics Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China
  • Received:2009-02-03 Revised:1900-01-01 Published:2009-12-15 Online:2009-12-15
  • Contact: DI Wen

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摘要： 卵巢癌死亡率居妇科恶性肿瘤之首。由于早期临床症状隐匿，缺乏有效的早期诊断方法，超过70%的患者就诊时已是临床晚期。早期卵巢癌患者5年生存率为70%～90%，而晚期卵巢癌患者的5年生存率仅为20%。因此，早期诊断对卵巢癌的预后有重要影响。近年研究者致力于寻找特异度、灵敏度高的血清肿瘤标志物，如CA125、卵巢癌差异蛋白4（HE4）、可溶性间皮素相关蛋白（SMRP）、人激肽释放酶（Hk）、CA72-4和骨桥蛋白（OPN）等，以及血清标记物的联合检测，并取得一系列进展。对卵巢癌早期诊断的血清肿瘤标志物研究进展综述。

关键词: 卵巢癌, 早期诊断, 血清肿瘤标记物, CA125

Abstract: Ovarian cancer is the first leading cause of cancer deaths among women. Because of early stage ovarian cancer′s hidden clinical symptoms, we lack effective early diagnostic methods causing more than 70% of patients diagnosed at advanced stage. Early stage ovarian cancer is associated with a 5-year survival rate of 70%-90%, 5-year survival rate for patients with advanced ovarian cancer is only 20%. Therefore, early diagnosis of ovarian cancer has an important impact on prognosis. In recent years, people committed to search for serum tumor markers of high specificity and sensitivity such as CA125, HE4, SMRP, CA72-4, Hk, OPN, and combined detection as well. Also they have made a series of progress which will be reviewed in this article.

Key words: Ovarian carcinoma, Early diagnosis, Serum tumor markers, CA125