国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (6): 465-468.

• 综述 • 上一篇    下一篇

组织因子途径抑制物-2与妇科肿瘤

张乔;张淑兰   

  1. 110004 沈阳, 中国医科大学附属盛京医院妇产科
  • 收稿日期:2008-11-28 修回日期:1900-01-01 出版日期:2009-12-15 发布日期:2009-12-15
  • 通讯作者: 张淑兰

The Relationship Between Tissue Factor Pathway Inhibitor-2 and Gynecological Tumors

ZHANG Qiao;ZHANG Shu-lan   

  1. Department of Gynecology and Obstetrics, the Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2008-11-28 Revised:1900-01-01 Published:2009-12-15 Online:2009-12-15
  • Contact: ZHANG Shu-lan

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摘要： 组织因子途径抑制物-2（TFPI-2）属于库尼（Kunitz）型丝氨酸蛋白酶抑制剂家族蛋白，是一种广谱的丝氨酸蛋白酶抑制物。大量研究表明，TFPI-2通过抑制和降解基质金属蛋白酶，抑制肿瘤新生血管生成，抑制TF-FVIIa复合物介导的信号转导途径以及诱导肿瘤细胞凋亡等机制调控某些恶性肿瘤细胞的侵袭和转移。就TFPI-2的分子生物学特点、与恶性肿瘤侵袭转移的关系，及其与妇科肿瘤关系的研究进展综述。

关键词: 组织因子途径抑制物-2, 基质金属蛋白酶, 侵袭, 转移, 妇科肿瘤

Abstract: Tissue factor pathway inhibitor-2（TFPI-2） belongs to the Kunitz-type serine proteinase inhibitor family, and it is a broad-spectrum inhibitor of serine proteinase. A great number of studies show that, TFPI-2 can inhibit and degrade matrix metalloproteinase, inhibit the angiogenesis and the signal transduction pathway mediated by TF-FVIIa compound and induce apoptosis of tumor cells to accommodate the invasion and metastasis of some malignant tumor. In this article, we reviewed progress in research on the feature of molecular biological of TFPI-2, its relationship with the invasion and metastasis of malignant tumor, and with gynecological tumors.

Key words: Tissue factor pathway inhibitor-2, Matrix metalloproteinase, Invasion, Metastasis, Gynecologic neoplasm