国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (2): 136-138.

• 论著 • 上一篇    下一篇

Smac/DIABLO在上皮性卵巢癌组织中的表达及临床意义

徐欣然,张虹   

  1. 300052 天津市中心妇产科医院肿瘤科
  • 收稿日期:2009-01-10 修回日期:1900-01-01 出版日期:2010-04-15 发布日期:2010-04-15
  • 通讯作者: 张虹

Expression of Smac/DIABLO in Epithelial Ovarian Carcinoma and Its Clinical Significance

XU Xin-ran, ZHANG Hong   

  1. Tianjin Central Obstetrics and Gynecology Hospital, Tianjin 300052, China
  • Received:2009-01-10 Revised:1900-01-01 Published:2010-04-15 Online:2010-04-15
  • Contact: ZHANG Hong

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摘要： 目的：探讨Smac/DIABLO在上皮性卵巢癌组织中的表达及临床意义。方法：采用免疫组化技术分别检测30例正常卵巢、30例良性上皮性卵巢肿瘤、30例交界性上皮性卵巢肿瘤及60例上皮性卵巢癌的组织中Smac/DIABLO蛋白的表达水平。结果：在上皮性卵巢癌中Smac/DIABLO阳性表达率为41.67%（25/60），低于良性上皮性卵巢肿瘤（83.33%，25/30）和正常卵巢组织（90.00%，27/30），差异有统计学意义（χ2＝14.06，P ＜0.008 3；χ2＝19.15，P ＜0.008 3）。且随组织学分级和临床分期增高，卵巢癌组织中Smac/DIABLO表达逐渐降低（F＝7.23，P ＜0.05；F＝4.48，P ＜0.05）。Smac/DIABLO阴性表达者生存期短于阳性表达者。结论：Smac/DIABLO在上皮性卵巢癌组织中阴性表达与上皮性卵巢癌不良预后相关。

关键词: 上皮性卵巢癌, Smac/DIABLO, 细胞凋亡, 免疫组化

Abstract: Objective: To investigate the expression of Smac/DIABLO in epithelial ovarian carcinomas and its clinical significance. Methods: The expression of Smac/DIABLO proteins was detected with immunohistochemistry. Results: The positive expression rate of Smac/DIABLO in ovarian carcinomas was significantly lower than that in benign ovarian tumors and normal ovaries（χ2=14.06, P <0.008 3; χ2=19.15, P <0.008 3）. In ovarian carcinomas, the expression of Smac/DIABLO was significantly decreased during progression from early to advanced tumour clinical stages and histological grade（F=7.23, P <0.05; F=4.48, P <0.05）. There was relationship between the low expression of Smac/DIABLO and poor prognosis of epithelial ovarian carcinomas. Conclusions: There was low expression of Smac/DIABLO in epithelial ovarian carcinomas, Smac/DIABLO was related to the poor prognosis of ovarian carcinomas.

Key words: Epithelial ovarian carcinomas, Smac/DIABLO, Apoptosis, Immunohistochemistry