国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (3): 187-189.

• 综述 • 上一篇    下一篇

野生型P53及其调控基因与子宫颈癌发病机制

朱靖,周颖,凌斌   

  1. 230001 合肥，安徽医科大学附属省立医院妇产科分子实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-15 发布日期:2010-06-15
  • 通讯作者: 周颖

Wild Type P53 and Its Regulatory Factors in the Pathogenesis of Cervical Cancer

ZHU Jing, ZHOU Ying, LING Bin   

  1. Laboratory of Molecular Biology, the Affiliate Provincial Hospital of Anhui Medical University, Hefei 230001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-06-15 Online:2010-06-15
  • Contact: ZHOU Ying

PDF (PC)

4899

摘要： P53基因是迄今发现与人类肿瘤的发生相关性最高的抑癌基因，在人类癌症中发生突变的频率高达50％。在子宫颈癌组织中表达则降低，且以野生型（wt）为主。wtP53第4外显子72密码的基因多态性与子宫颈癌发病机制密切相关。wtP53蛋白在子宫颈癌细胞中半衰期短，功能易失活，具有调节细胞周期、促进肿瘤细胞凋亡、抑制肿瘤细胞生长的功能。其功能失活与多种基因，如E6，E7，MDM2和STAT3等基因的降解作用有关。

关键词: 野生型P53, 人乳头瘤病毒, 子宫颈癌, 凋亡

Abstract: P53 gene is one of the most important human tumor suppressor genes relative to tumorigenesis，and its mutations are found in approximately 50% of cancers. Though P53 is expressed lower in cervical cancer tissues with the main wild-type. The codon 72 polymorphism in exon 4 of wtP53 is closely associated with occurrence of cervical carcinomas. In cervical cancer cells the half-life of wtP53 protein is shorter, and the function is inactivated. wtP53 regulate of cell cycle, promotion of tumor cells apoptosis, and inhibition of tumor cell growth. A variety of genes such as E6, E7, MDM2, STAT3 can inactivate wtP53 and induce the degradation of wtP53.

Key words: Wild type P53, Human papillomavirus, Cervical cancer, Apoptosis