国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (4): 264-266.

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Nrf2-Keap1-ARE信号通路与肿瘤耐药相关性

李仲慜， 易晓芳，孙 红   

  1. 200011 上海，复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 孙 红

The Relation of Nrf2-Keap1-ARE Signaling Pathway to Chemoresistance

LI Zhong-min，YI Xiao-fang，SUN Hong   

  1. Hospital of Obstetrics and Gynecology，Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-08-15 Online:2010-08-15
  • Contact: SUN Hong

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摘要： 肿瘤耐药是影响肿瘤化学治疗的主要问题。肿瘤细胞产生耐药的机制及如何逆转耐药是亟待解决的重要问题。已知肿瘤耐药机制包括：肿瘤细胞内药物泵出增多、体内非特异解毒过程加强、DNA损伤修复能力增强、细胞凋亡抑制等。但主导机制或者说关键基因还是困扰耐药研究的主要难题。新近研究发现，以NF-E2相关因子2（Nrf2）为主体的该信号通路可能与多种耐药机制相关联，从而解释多种肿瘤耐药的原因。简述Nrf2-Keap1-ARE信号通路的组成及其与肿瘤耐药的相关性研究。

关键词: 转录因子, NF-E2相关因子2-胞质伴侣蛋白-抗氧化反应元件, 信号通路, 抗药性, 肿瘤

Abstract: Chemoresistance is the main bottleneck which restricts the effect of chemotherapy on cancer cells. Why cancer cells produce chemoresistance and how to solve the problem is the urgent concern for oncologists. Although some mechanisms have been reported， such as the increase of drug effluence， the strengthening of non-specific detoxification process， the enhanced DNA damage repair and apoptosis inhibition， the major factor or dominant mechanism underling chemoresistance remains the main problem. Recent study has shown that the Nrf2-Keap1-ARE signaling pathway may be the key point which links a variety of mechanisms for chemoresistance， and through genetic engineering on this pathway cancer cells may regain chemosensitivity. The composition of Nrf2-Keap1-ARE signaling pathway will be described and the research on the correlation between this pathway and chemoresistance will be reviewed in this paper.

Key words: Transcription factors, Nrf2-Keap1-ARE, Signaling pathway, Drug resistance, Neoplasm