国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (1): 29-32.

• 综述 • 上一篇    下一篇

子宫内膜异位症与CYP 19基因多态性

王丹菡 王乐丹 吕杰强   

  1. 325000 温州市袁温州医学院附属二院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-15 发布日期:2011-02-15
  • 通讯作者: 吕杰强

Endometriosis and CYP 19 Gene Polymorphisms

WANG Dan-han, WANG Le-dan, LU Jie-qiang   

  1. The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-02-15 Online:2011-02-15
  • Contact: LU Jie-qiang

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摘要： 子宫内膜异位症（EMs）是妇科常见疾病之一，该病在病理上呈良性形态学改变，但具有类似恶性肿瘤的种植、侵袭及远处转移能力。EMs是一种雌激素依赖性疾病，CYP 19基因的表达与雌激素的产生密切相关，其突变可能会改变雌激素的暴露情况，影响EMs的发病风险。目前关于CYP 19基因多态性与EMs之间的关系仍存在争论，尚需深入研究以明确芳香化酶的基因多态性在EMs发生中的作用。

关键词: 子宫内膜异位症, 芳香酶, 等位基因, 突变, 多态性, 限制性片段长度, 雌激素类

Abstract: Endometriosis（EMs） is one of the common gynecological diseases, the pathology showed benign morphological changes of but with a similar malignant tumors characteristics of planting, erosion and distant metastasis. EMs is an estrogen-dependent diseases, CYP 19 gene expression is closely related to the production of estrogen, and its mutations may alter estrogen exposure, thereby affecting the pathogenesis of endometriosis. Currently on the CYP 19 gene polymorphism and the relationship between EMs are still controversial and need further study to clarify the role of the aromatase gene polymorphism in the occurrence of EMs.

Key words: Endometriosis, Aromatase, Alleles, Mutation, Polymorphism, restriction fragment length