国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (1): 49-52.

• 综述 • 上一篇    下一篇

微小RNA在妇科肿瘤中的研究进展

毛晓丹 孙蓬明   

  1. 350001 福州袁福建省妇幼保健院袁福建省妇儿医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-15 发布日期:2011-02-15
  • 通讯作者: 孙蓬明

The Research Progress of MicroRNA on Gynecological Cancer

MAO Xiao-dan, SUN Peng-ming   

  1. Institute of Gynecologic Oncology, Fujian Maternal and Child Health Hospital, Fuzhou 350001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-02-15 Online:2011-02-15
  • Contact: SUN Peng-ming

PDF (PC)

4786

被引次数

5

摘要： 微小RNA（microRNA，miRNA）是一类在动植物中广泛存在的内源性21~25个核苷酸的短序列、高度保守的小分子非编码RNA。这类分子调节基因的表达，参与细胞分化、增殖和凋亡，肿瘤的发生、DNA甲基化及染色质改变等一系列的重要进程。综述miRNA的生物合成、作用机制及在妇科肿瘤中的一些研究进展。

关键词: 微RNAs, 卵巢肿瘤, 宫颈肿瘤, 子宫内膜肿瘤, 基因表达调控, DNA甲基化

Abstract: MicroRNA（miRNA）, which are small noncoding RNAs of 21-25 nucleotides in length existed in animals and plants, is characteristic of high conservation and endogenous. They regulate the expression of genes and take part in cell differentiation, proliferation, apoptosis, and tumorigenesis, DNA hypomethylation, chromphil change and so on. The article elaborares miRNA whose biosynthesis, mechanism of action and improvements of some studies in gynecological neoplasms.

Key words: MicroRNAs, Ovarian neoplasms, Uterine cervical neoplasms, Endometrial neoplasms, Gene expression regulation, DNA methylation