国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 386-389.

• 综述 • 上一篇    下一篇

表观遗传学在产科领域的研究进展

常 颖, 陈 叙   

  1. 300100 天津市中心妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15

Epigenetics’s Research Progress in Obstetrics

CHANG Ying，CHEN Xu   

  1. Tianjin Central Hospital for Obstetrics and Gynecology，Tianjin 300100，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15

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摘要： 表观遗传学是研究表观遗传变异的遗传学分支学科。近年来，随着研究的深入，表观遗传学已在人类生长发育中的某段时期以及妊娠特发性疾病的发生及其防治方面显示其不可估量的作用和广阔的前景。在哺乳动物的生殖细胞发育时期和植入前胚胎期，其基因组范围内的甲基化模式通过大规模的去甲基化和接下来的再甲基化过程发生重编程，从而产生具有发育潜能的细胞。妊娠期间的环境因素包括接触有毒有害物质、内分泌干扰物以及食物、药品等均可改变表观遗传模式，导致妊娠妇女及其后代发生各种疾病。

关键词: 基因组印迹, DNA甲基化, 胎儿生长迟缓, 先兆子痫, 表观遗传学

Abstract: Epigenetics is the study branch of genetic variation of apparent genetics. In recent years，with further research，epigenetics displays their invaluable role and broad prospects in human growth and development period and the idiopathic pregnant diseases and their prevention and control. In mammalian germ cells and preimplantation developmental stages，its occurs genome methylation patterns through the large-scale demethylation and then re-methylation reprogramming，resulting in a developmental potential cells. Environmental factors during pregnancy，including exposure to toxic hazardous substances，endocrine disruptors，as well as food，medicines can change the epigenetic model，leading to various diseases in pregnant women and their offspring.

Key words: Genomic imprinting, DNA methylation, Fetal growth retardation, Pre-eclampsia, Epigenetics