国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (6): 537-540.

• 综述 • 上一篇    下一篇

miR-21与妇科肿瘤关系的研究进展


闫莉丽, 欧阳玲   

  1. 110004 沈阳,中国医科大学附属盛京医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-12-15 发布日期:2011-12-15
  • 通讯作者: 欧阳玲

Advancements of miR-21 and Gynecologic Neoplasms

YAN Li-li，OUYANG Ling   

  1. Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-12-15 Online:2011-12-15
  • Contact: OUYANG Ling

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被引次数

13

摘要： 微小RNA（miRNA）是一类分布十分广泛的内源性非编码RNA，在动物、植物和病毒中广泛存在。miRNA与肿瘤的发生、发展和预后有关，并在肿瘤的增殖、分化及凋亡等方面有重要的作用。大量研究结果表明，许多miRNA可作为原癌基因或抑癌基因，在肿瘤的发生和发展中发挥重要作用，其中miR-21最受重视。miR-21作为较早发现的人类miRNA之一，因其较为明确的存在背景，而成为人类miRNA功能研究中的重要工具。就miR-21与妇科肿瘤关系的研究进展做综述。

关键词: 微RNAs, 生殖器肿瘤, 女（雌）性, 卵巢肿瘤, 宫颈肿瘤, 癌基因

Abstract: MicroRNA（miRNA） are small，noncoding single-stranded RNA that are ubiquitous in both animals，
plants and viruses. miRNA is concerned with tumor development and prognosis， and plays a crucial role in tumor hyperplasia， differentiation and apoptosis. Lots of results suggest that many miRNAs may play oncogenic or anti-oncogen role in the tumor development，and the miR-21 is paid the most attention. miR-21，one of the early discovered miRNAs in human cells，over-expressed in HeLa cells is a popular model applied functional study of human miRNAs. In this review，we have summarized the research of the relationship of miR-21 and gynecologic neoplasms.

Key words: MicroRNAs, Genital neoplasms, female, Ovarian neoplasms, Uterine cervical neoplasms, Oncogenes