国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (2): 119-124.

• 综述 • 上一篇    下一篇

雄激素过多在多囊卵巢综合征发生发展中的作用

丁 涛 ,郑艳华 , 谢 军, 马红霞, 吴效科   

  1. 院510182 广州医学院(丁涛,郑艳华,谢军);广州医学院第一附属医院中医科(马红霞);黑龙江中医药大学第一附属医院妇产科(吴效科)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 马红霞

The Impact of Androgen Excess on the Initiation and Development of Polycystic Ovary Syndrome

DING Tao，ZHENG Yan-hua，XIE Jun，MA Hong-xia，WU Xiao-ke   

  1. Guangzhou Medical College，Guangzhou 510182，China（DING Tao，ZHENG Yan-hua，XIE Jun）；Department of Traditional Chinese Medicine，the First Affiliated Hospital of Guangzhou Medical College，Guangzhou 510120，China（MA Hong-xia）；Department of Obstetrics and Gynecology，the First Affiliated Hospital，Heilongjiang University of Chinese Medicine，Harbin 150040，China（WU Xiao-ke）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-04-15 Online:2012-04-15
  • Contact: MA Hong-xia

PDF (PC)

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摘要： 目前多囊卵巢综合征（PCOS）的病因仍不十分明确，尚未发现其确切致病基因，不少研究表明雄激素过多与PCOS的发生密切相关，可能是促进其发生发展的重要因素。现普遍认为高雄激素血症是PCOS发病的根本原因之一，表现为特异性症状和并发症。然而，卵巢多小卵泡、不排卵和胰岛素抵抗的生育期妇女雄激素水平较高，使症状与并发症恶化，这就导致高雄激素血症的恶性循环。就高雄激素血症导致PCOS进行综述。

关键词: 雄激素类, 多囊卵巢综合征, 卵巢, 无排卵, 胰岛素抗药性

Abstract: Although the aetiology of polycystic ovary syndrome（PCOS） is unknown and the search for causative genes is elusive，androgen excess is generally thought of an important triggers of PCOS.We known that excess androgens is the root cause of PCOS starting from the female fetus，producing the characteristic signs and symptoms which are then exacerbated by the excess ovarian androgen production from multiple small follicle，anovulation and insulin resistance in the reproductive life-span，thus setting up a vicious perpetual circle of excess androgen.The paper is biased in support of the hypothesis that androgen excess is the“root of all evil”in PCOS.

Key words: Androgens, Polycystic ovary syndrome, Ovary, Anovulation, Insulin resistance