铁皮石斛多糖对多囊卵巢综合征的潜在治疗作用

doi:10.12280/gjfckx.20251219

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种常见的生殖内分泌代谢紊乱性疾病，其发病机制复杂，涉及胰岛素抵抗、高雄激素血症、慢性炎症及卵巢功能异常等多方面。当前西医治疗主要以对症处理为主，存在一定的局限性。铁皮石斛作为一种传统名贵中药材，具有滋阴清热、益胃生津之功效，在中医临床上可用于调理妇科疾病。铁皮石斛多糖（Dendrobium officinale polysaccharide，DOP）是其最主要的生物活性成分，近年研究表明DOP在调节糖脂代谢、抗炎、抗氧化及调节免疫等方面展现出显著活性，这些作用与PCOS的核心病理高度相关。探讨DOP通过改善胰岛素抵抗、调节激素水平、抑制卵巢局部炎症与氧化应激、恢复卵巢自噬功能以及调节肠道菌群等多途径干预PCOS的潜在机制，以期为DOP作为PCOS的潜在治疗策略提供理论依据，并为中药现代化研究提供新的思路。

关键词: 铁皮石斛, 多糖类, 多囊卵巢综合征, 胰岛素抵抗, 氧化性应激, 胃肠道微生物组

Abstract:

Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine and metabolic disorder characterized by a complex pathogenesis involving insulin resistance, hyperandrogenemia, chronic inflammation, and ovarian dysfunction. Current Western medical management primarily focuses on symptomatic treatment, which has certain limitations. Dendrobium officinale, a valuable traditional Chinese medicinal herb, is known for its effects in nourishing yin clearing heat and reinforcing stomach regenerating fluid, and has been used in traditional medicine to regulate gynecological disorders. Dendrobium officinale polysaccharide (DOP), its primary bioactive component, has recently been shown to exhibit significant activities in regulating glucose and lipid metabolism, anti-inflammatory and antioxidant effects, and immunomodulation. These biological properties are highly relevant to the core pathologies of PCOS. This review discusses the potential mechanisms through which DOP may intervene in PCOS, including ameliorating insulin resistance, modulating hormonal levels, inhibiting local ovarian inflammation and oxidative stress, restoring ovarian autophagy function, and regulating the gut microbiota. The aim is to provide a theoretical basis for DOP as a potential therapeutic strategy for PCOS and to offer new insights for modern research on traditional Chinese medicine.

Key words: Dendrobii officmalis caulis, Polysaccharides, Polycystic ovary syndrome, Insulin resistance, Oxidative stress, Gastrointestinal microbiome

蔡豪琴, 王宇, 张茜, 余健楠, 石百超, 吴效科. 铁皮石斛多糖对多囊卵巢综合征的潜在治疗作用[J]. 国际妇产科学杂志, 2026, 53(2): 131-136.

CAI Hao-qin, WANG Yu, ZHANG Xi, YU Jian-nan, SHI Bai-chao, WU Xiao-ke. Potential Therapeutic Effects of Dendrobium Officinale Polysaccharide in Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2026, 53(2): 131-136.

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