国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (2): 115-118.

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高雄激素血症检测项目与雄激素测定方法

黄美凤,赵晓苗,杨冬梓   

  1. 510120 广州，中山大学孙逸仙纪念医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 杨冬梓

Discuss the Detecting Items of Hyperandrogenism and the Measurement Methods of Androgen

HUANG Mei-feng，ZHAO Xiao-miao，YANG Dong-zi   

  1. Reproductive Center，SUN Yat-sen Memorial Hospital，SUN Yat-sen University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-04-15 Online:2012-04-15
  • Contact: YANG Dong-zi

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摘要： 高雄激素血症是多囊卵巢综合征（polycystic ovarian syndrome，PCOS）的基本特征之一。由于PCOS在育龄女性中发病率高，故早发现、早治疗对该病尤其重要。目前全世界可进行雄激素检测的医院中，仍在用酶联免疫吸附测定（ELISA）法检测游离雄激素，化学发光法检测总雄激素。国际上已有许多关于雄激素检测的方法，结果显示，这些方法在检测女性低血清雄激素水平的敏感度较差；同时雄激素的测定项目至今仍未取得一致共识。这提示目前可能有大部分伴有高雄激素血症的患者未得到诊断。放射免疫法及质谱法定量检测雄激素是较为准确的检测方法，但因各种因素未能应用于临床，对PCOS的诊断和治疗造成很大困难。

关键词: 多囊卵巢综合征, 雄激素增多症, 放射免疫测定, 色谱法, 高压液相

Abstract: Hyperandrogenism is one of the common features of polycystic ovarian syndrome（PCOS）. It is very important to discover and treat this disease early because of its high prevalent rate in the reproductive age women. Nowadays，the hospitals in all over the world still use ELISA to detect the Free testosterone and chemiluminescence to detect the Total testosterone. There are many studies about the assay methods and projects for androgen and most studies demonstrated that these assay methods for testosterone have been fraught with accuracy problems；they are not sensitive for the females because of their low serum androgen concentration. Meanwhile，the androgen determination projects still has not reached the consistent mutual recognition. It prompts there is possiblily a majority patients accompanied by hyperandrogenism have not been diagnosed. Radioimmunoassay analysis and the mass spectrometrybased methods are considered to be the highly effective，but it is very difficult to use in the clinic and diagnose the disease because of many reasons.

Key words: Polycystic ovary syndrome, Hyperandrogenism, Radioimmunoassay, Chromatography, high pressure liquid