国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (2): 137-140.

• 综述 • 上一篇    下一篇

Wnt信号通路与子宫肌瘤相关性研究进展

史 杨 , 赵 莉, 曹 阳 , 周洁云, 杨 英, 张婷婷   

  1. 201203 上海中医药大学(史杨);上海市岳阳中西医结合岳阳医院妇科(赵莉,曹阳,杨英,张婷婷);上海市计划生育研究所(周洁云)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 张婷婷

Progress About Wnt Signal Pathway and Uterine Leiomyoma

SHI Yang，ZHAO Li，CAO Yang，ZHOU Jie-yun，YANG Ying，ZHANG Ting-ting   

  1. Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China（SHI Yang）； Department of Gynecology，Yueyang Integrated Chinese Medicine and Western Medicine Hospital，Shanghai 200437，China（ZHAO Li，CAO Yang，YANG Ying，ZHANG Ting-ting）； Shanghai Institute of Planned Parenthood Research，Shanghai 200032，China（ZHOU Jie-yun）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-04-15 Online:2012-04-15
  • Contact: ZHANG Ting-ting

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摘要： Wnt信号通路是调节细胞发育和生长的一个关键途径，在正常情况下对胚胎发育和成人部分组织的形成和功能发挥起着重要作用。其异常激活则参与了人类多种肿瘤的发病过程，目前研究表明，Wnt通路中的多种因子与子宫肌瘤的发生发展有关，通过影响细胞凋亡、血管生成等发挥作用，并可与多种生长因子相互影响。但某些Wnt分子在子宫肌瘤中的表达尚存一定的争议。就Wnt信号通路与子宫肌瘤关系的研究进展进行简要综述。

关键词: 蛋白质类, 信号传导, 子宫肿瘤, 肌瘤

Abstract: Wnt signal pathway is a key way to regulate cell development and growth. In normal circumstances，it plays a significance role on the embryonic development and tissue formation. Its abnormal activation is involved in the pathogenesis of many human tumors. The present study show that a variety of molecules of Wnt signal pathway are closely related to the occurrence and development of uterine leiomyoma，which play roles by influencing apoptosis， angiogenesis，etc，and have interaction with many kinds of growth factors. However，some Wnt molecules expressed in the uterine leiomyoma is still disputed. This article is a brief review about recent advances in Wnt signal pathway and its relation to uterine leiomyoma.

Key words: Proteins, Signal transduction, Uterine neoplasms, Myoma