国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (5): 514-517.

• 综述 • 上一篇    下一篇

促性腺激素释放激素类似物在妇科恶性肿瘤中的应用

刘石萍, 杨佳欣   

  1. 100730 中国医学科学院北京协和医学院北京协和医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-10-15 发布日期:2012-10-15
  • 通讯作者: 杨佳欣

Application of Gonadotrophin-Releasing Hormone Analogs in Malignant Gynecological Neoplasms

LIU Shi-ping，YANG Jia-xin   

  1. Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Chinese Academy of Medical Science & Peking Union Medical College，Beijing 100730，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-10-15 Online:2012-10-15
  • Contact: YANG Jia-xin

PDF (PC)

4967

被引次数

9

摘要： 根据作用机制不同，促性腺激素释放激素类似物（GnRH-A）可分为两类：激动剂和拮抗剂。研究证实，约80%的卵巢癌以及子宫内膜癌能够表达GnRH及其受体，GnRH-A通过间接抑制下丘脑-垂体-性腺轴或通过自分泌及旁分泌直接抑制肿瘤细胞的增殖。GnRH-A曾被用于治疗晚期或复发的子宫内膜癌和卵巢癌，但疗效不明显。而目前研究的热点是将GnRH-A用于保留早期子宫内膜癌患者的生育功能以及保护肿瘤化疗患者的卵巢功能。GnRH-A还可用于妇科恶性肿瘤的靶向治疗。

关键词: 促性腺素释放激素, 受体, LHRH, 生殖器肿瘤, 女（雌）性, 治疗, 卵巢

Abstract: According to its mechanisms of action，gonadotrophin-releasing hormone analogs　（GnRH-A）　are divided into two categories：agonist and antagonist． It has been demonstrated that 80% of ovarian and endometrial cancers express GnRH and its receptors． The anti-cancer role of GnRH-A is played either by suppressing the hypothalamic-pituitary axis or through its autocrine and paracrine systems． GnRH-A had been used in the treatment of advanced or recurrent endometrial and ovarian cancers，but the effect is no better than other second-line drugs．These days，the application of GnRH-A in the preservation of fertility and ovarian function has become increasingly popular． Besides，the use of GnRH-A in molecular targeted therapy is also promising.

Key words: Gonadotropin-releasing hormone, Receptors, LHRH, Genital neoplasms, female, Therapy