国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (1): 24-26.

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多囊卵巢综合征动物模型的胰岛素抵抗表现

杜丹峰, 李雪莲   

  1. 200030 上海,复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 李雪莲

Insulin Resistance Performance of Animal Models of Polycystic Ovary Syndrome

DU Dan-feng，LI Xue-lian   

  1. Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200030，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15
  • Contact: LI Xue-lian

PDF (PC)

5118

被引次数

22

摘要： 多囊卵巢综合征（PCOS）是育龄期妇女常见内分泌及代谢紊乱性疾病，病因不明，近年来越来越多的研究显示，高胰岛素血症和胰岛素抵抗在疾病发生发展过程中起到重要作用。进行疾病发生机制及治疗效果的研究通常应用动物模型，常见的多囊卵巢动物模型造模方法包括雄激素法、雄激素+人绒毛膜促性腺激素（hCG）法、雌激素法、来曲唑法、胰岛素+hCG法、孕激素+hCG法等。分析比较PCOS研究中常用的几种动物模型，探讨更适合研究胰岛素抵抗的动物模型。

关键词: 多囊卵巢综合征, 疾病模型, 动物, 胰岛素抗药性

Abstract: Polycystic ovary syndrome（PCOS），whose etiology is still not clear，is a common endocrine disorder of reproductive-age female. More and more researches indicate that hyperinsulinemia and insulin resistance play an important role in the occurrence and development of PCOS in recent decades. Usually，we use a variety of animal models for the study of it’s pathogenesis and therapeutic effect. Common polycystic ovary animal model manufacturing methods include androgen， androgen+hCG， estrogen method， letrozole method， insulin + hCG method， progesterone + hCG method， this paper summarizes the insulin resistance performance of common animal models of polycystic ovary syndrome ， and to explore which model is more suitable for the study of insulin resistance in the occurrence and development of the disease.

Key words: Polycystic ovary syndrome, Disease models, animal, Insulin resistance