国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (1): 27-30.

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干细胞在子宫内膜异位症发病中的意义

于聪祥, 宋静慧   

  1. 010059 呼和浩特,内蒙古医科大学
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 宋静慧

Significance of Stem Cells in the Pathogenesis of Endometriosis

YU Cong-xiang，SONG Jing-hui   

  1. Inner Mongolia Medical University， Hohhot 010059，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15
  • Contact: SONG Jing-hui

PDF (PC)

5122

被引次数

21

摘要： 子宫内膜异位症（endometriosis，EMs）是多因素疾病，至今病因不明。研究证明，子宫内膜存在干/祖细胞，包括胚胎残留干细胞或骨髓来源干细胞，这些干/祖细胞介导子宫内膜的周期性再生。越来越多的研究通过寻找特异性干细胞标记物以分离并鉴定子宫内膜干/祖细胞，并提出了EMs的干细胞起源学说，认为子宫内膜干/祖细胞异常分化增殖可能导致EMs发生。各种来源的干细胞是“种子”，而逆流经血、雌激素治疗及局部微环境是“土壤”，只要局部组织同时存在“种子”和“土壤”，EMs就会发生。这一学说为EMs发病机制及临床诊疗研究提供了新思路。

关键词: 干细胞, 成体干细胞, 子宫内膜异位症, Musashi-1

Abstract: The pathogenesis of endometriosis（EMs） which is multifactorial remains unclear. Studies have proved there are stem/progenitor cells（SC） in endometrium，including endometrium-derived and bone marrow-derived SC，which induce the periodic regeneration of endometrium. More and more studies attempt to identify specific markers of SC in order to isolate and characterize endometrial SC. And they put forward the endometrial stem cell hypothesis of EMs，which consider EMs is induced by abnormal proliferation and differentiation of SC. All kinds of stem cells provide the“seeds”，while menstrual reflux， estrogen therapy and the microenvironment provide the“soil”. Once the seeds meet the soil，EMs will occure. This hypothesis uncovers a new era of the pathogenesis and clinical research on EMs.

Key words: Stem cells, Adult stem cells, Endometriosis, Musashi-1