国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (1): 3-6.

• 综述 • 上一篇    下一篇

PIGF、sVEGFR-1和sEng对调节血管平衡与死胎发生的研究进展

张泽华, 许 多,王晨虹   

  1. 518028 深圳,南方医科大学深圳市妇幼保健院产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 许 多

Research Progress of PIGF，sVEGFR-1，sEng’s Regulation of Blood Vessel Balance with Stillbirth

ZHANG Ze-hua，XU Duo，WANG Chen-hong   

  1. Department of Obstetrics，Maternal and Child Health Hospital of Shenzhen City，Shenzhen 518028，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15
  • Contact: XU Duo

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5127

被引次数

2

摘要： 目前很多领域已开展对血管生成因子与抗血管生成因子的研究，其在病理产科中的作用机制已成为研究热点，尤其在子痫前期妊娠妇女血浆中的研究较多，但对其在死胎中的作用尚少见报道。探讨死胎临床病因学与胎盘生长因子（PIGF）、可溶性血管内皮生长因子受体1（sVEGFR-1）、可溶性内皮因子（sEng）变化的意义，以及不同原因死胎母亲羊水及母体血清VEGFR-1、PIGF、和sEng浓度的变化，并探讨血管生成因子及抗血管生成因子变化与死胎发生的关系，为死胎的病因及发病机制研究开辟新思路。

关键词: 死胎, 血管生成诱导剂, 血管内皮生长因子受体1, 病理学

Abstract: Angiogenic factors and anti-angiogenic factors have been studied in many areas. Now，they have become a hot spot in the pathological obstetrics，many researches are on the preeclampsia in maternal plasma，but the role of them in stillbirth is still ralely reported. This paper mainly discusses the clinical etiology of stillbirth，the significance of PIGF、 sVEGFR-1、sEng′s change and the reasons for stillbirth of amniotic fluid and maternal serum of endothelial growth factor receptor-1、placental growth factor and soluble endoglin sEng concentration. We make a detailed study of the relationship between changes of anti-angiogenic and anti-angiogenic factor and the occurrence of stillbirth，open up new ideas for the etiology and pathogenesis of stillbirth.

Key words: Fetal death, Angiogenesis inducing agents, Vascular endothelial growth factor receptor-1, Pathology