国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (1): 47-49.

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HPV L1蛋白在预测宫颈病变中的研究进展

肖 倩, 张淑兰   

  1. 110001 沈阳,中国医科大学附属盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 张淑兰

Research Development of　Detection of HPV L1 Capsid Protein in Predicting Development of the Cervical Disease

XIAO Qian，ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology，Shengjing Hospital of China Medical University，Shenyang 110001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15
  • Contact: ZHANG Shu-lan

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被引次数

5

摘要： 宫颈癌是妇科肿瘤中的第二大常见肿瘤，现已明确人乳头瘤病毒（HPV）感染是宫颈癌的主要致病因素，但并非所有HPV感染都会导致宫颈癌。HPV L1蛋白是HPV的主要衣壳蛋白，其表达与HPV的复制及其早期感染密切相关。近年研究表明，在目前细胞学基础上检测病变组织HPV L1蛋白可提高宫颈病变筛查及预测病变进展的准确度，预防宫颈病变的过度诊治。综述HPV L1在预测宫颈病变的发展及预后的科学性及实用性，以寻找更加合理的筛查流程，对不同患者选择不同的治疗方案。

关键词: 乳头状瘤病毒科, 病毒蛋白质类, 宫颈上皮内瘤样病变, 乳头状瘤病毒疫苗, 预后

Abstract: Cervical cancer is the second most common tumor in gynecologic oncology，HPV L1 protein is the major capsid protein of HPV，and it′s expression is closely related to viral replication and early infection. Recent study shows that present screening method simultaneously unites HPV L1 capsid protein　detection may　enhances the accuracy for the screening cervical　disease　and　prediction of progression of lesions． This review is concentrated on update scientific nature and the usability　of the research for detection of HPV L1　capsid protein　in predicting the prognosis and development of cervical disease　a review，looking for the more reasonable screening flow，and choosing the different therapeutic schedule for different patients.

Key words: Papillomaviridae, Viral proteins, Cervical intraepithelial neoplasia, Papillomavirus vaccines, Prognosis