国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 222-225.

• 综述 • 上一篇    下一篇

可溶性血管内皮生长因子受体-1与胎盘生长因子在子痫前期

杨智宇,陈立芬   

  1. 243000 安徽省马鞍山市妇幼保健院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15

The Significance of Clinical Studies of sFlt-1 and PLGF in Preeclampsia

YANG Zhi-yu，CHEN Li-fen   

  1. Maanshan Maternal and Child Care Service Center，Maanshan 243000，Anhui Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15

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摘要： 归纳子痫前期的病理生理过程以及可溶性血管内皮生长因子受体-l（sFlt-1）、胎盘生长因子（PLGF）与子痫前期的研究情况，PLGF是血管内皮生长因子（VEGF）家族成员之一，PLGF与Flt-1受体结合时，发挥促血管生成和促绒毛滋养细胞增殖、浸润的效应，而这些生物学功能均可被sFlt-1阻断，且sFlt-1对PLGF具有强效的拮抗作用，调节PLGF的功能。在子痫前期妊娠妇女血清中sFlt-1的水平升高，早于疾病的发生。子痫前期患者血浆中PLGF的水平降低。总结sFlt-1、PLGF预测诊断子痫前期发生及病情严重程度的研究进展，探讨sFlt-1、PLGF在子痫前期临床诊断中的意义。

关键词: 先兆子痫, 血管内皮生长因子受体-l, 胎盘生长因子

Abstract: This summary aims to generalize the pathological process of the preeclampsia and its relationship with sFlt-1 and placental growth factor（PLGF）. PLGF is a member of the VEGF family，PLGF binds with Flt-1 receptor，and promotes
angiogenesis and trophoblast proliferation. These biological functions can be blocked by sFlt-1 receptor，sFlt-1 plays an important role in regulation PLGF. sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease. Levels of PLGF are lower in preeclampsia serum compare to normal. This summarizes up the roles sFlt-1 and PLGF have played in the prediction of the diagnosis of preeclampsia as well as its seriousness， exploring the significance of the application of sFlt-1 and PLGF in the clinical diagnosis of preeclampsia.

Key words: Pre-eclampsia, Vascular endothelial growth factor receptor-1, Placental growth factor