国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 237-240.

• 综述 • 上一篇    下一篇

丝裂原活化蛋白激酶信号通路与子宫内膜异位症关系的研究进展

张 华,朱颖军   

  1. 300070 天津医科大学研究生院（张华）；天津市中心妇产科医院妇科（朱颖军）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15

Research Progress of MAP Kinase Signal Pathway and Endometriosis

ZHANG Hua，ZHU Ying-jun   

  1. Graduate School，Tianjin Medical University，Tianjin 300070，China（ZHANG Hua）；Department of Gynecology，Tianjin Central Hospital ofObstetrics and Gynecology，Tianjin 300100，China（ZHU Ying-jun）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15

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4934

被引次数

1

摘要： 子宫内膜异位症（endometriosis，EMs）是子宫内膜腺体和基质种植于子宫腔以外的雌激素依赖性疾病，系育龄妇女常见病。异位内膜的侵袭性种植是一个多因素参与的复杂过程，涉及多条信号转导通路，其中丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK）信号通路起了非常重要的作用。MAPK 信号通路与雌激素受体 （estrogen receptor，ER）调控关系密切，两者的相互作用在促异位内膜细胞增殖、促炎症因子生成和促血管生成方面均起了重要作用。就MAPK信号通路与EMs的关系作一综述，为更好地理解EMs的发病机制提供新的思路。

关键词: 子宫内膜异位症, JNK丝裂原活化蛋白激酶类, p38丝裂原活化蛋白激酶类, 雌激素类, 信号通路

Abstract: Endometriosis（EMs） is an estrogen-dependent disease characterized by extrauterine implantation and ectopic growth of endometrium and it’s a common disease of women of reproductive age. The invasive implantation of ectopic endometrium is a complicated procedure，which involves in multiple factors and a few signaling pathways and mitogen activated protein kinase signaling pathway plays the important role. The signaling regulation between MAPK pathway and ERs is intimate. The interaction between MAPK and ER plays important roles in stimulating the proliferation of endometriotic cell，the production of inflammatory factors and the neovascularization.On this basis，this article reviewes the relationship between MAPK signal pathway and the pathogenesis of endometriosis to better understand the mechanism of endometriosis with new ideas.

Key words: Endometriosis, JNK mitogen-activated protein kinases, p38 mitogen-activated protein kinases, Estrogens, Signal pathway