国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (6): 521-524.

• 综述 • 上一篇    下一篇

四跨膜蛋白超家族成员在胚胎植入中的作用

梁营秋, 高天旸   

  1. 510317 广州，南华大学教学医院广东省第二人民医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-12-15 发布日期:2013-12-15
  • 通讯作者: 高天旸

The Role of Transmembrane 4 Superfamily Members in the Embryonic Implantation

LIANG Ying-qiu，GAO Tian-yang   

  1. Department of Reproductive Medicine，Teaching Hospital of South China University Guangdong No.2 Provincial People′s Hospital，Guangzhou 510317，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-12-15 Online:2013-12-15
  • Contact: GAO Tian-yang

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摘要： 胚胎植入是哺乳动物生殖过程的关键环节。妊娠的正常建立和维持依赖囊胚与容受态子宫内膜间的相互作用，其中滋养细胞精确的侵入程度和子宫内膜的蜕膜化起重要作用。与肿瘤转移相似，滋养细胞侵袭子宫内膜也包括识别、黏附、侵袭、转移等过程，不同的是滋养细胞的侵袭行为具有“自限性”，是由一个复杂的网络系统精确调控的。四跨膜蛋白超家族成员以其在调控细胞黏附、侵袭、转移中独特的生物学作用，不仅在肿瘤转移中起重要作用，也在胚胎植入过程中扮演重要角色。

关键词: 复合体, 糖蛋白, 细胞膜, 滋养层, 侵袭性, 胚胎植入

Abstract: The implantation of the blastocyst into the maternal uterus is a crucial step in mammalian reproduction. The successful establishment of pregnancy requires an interaction between the blastocyst and receptive uterus，then trophoblasts invade the endometrium accurately. And the decidualization of endometrium is considered a major factor in this process. Similar to tumor metastasis，embryonic implantation also include identification，adhesion，invasion and transfer process. Differently，the invasion of trophoblast has a “self-limited” cell behavior，and it is exactly controled by a complex network of various cells and molecules. Transmembrane 4 superfamily members play an important role in a series of biological actions，such as cell adhesion，invasion and transfer，not only in the tumor metastasis，but also in the embryonic implantation.

Key words: Compomers, Glycoproteins, Cell membrane, Trophoblasts, Invasive, Embryo implantation