国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (1): 35-38.

• 综述 • 上一篇    下一篇

肿瘤细胞与淋巴管内皮细胞的交互作用及转移

刘颖蕾，谢静燕   

  1. 210006 南京医科大学附属南京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 谢静燕

Study on Relationship between Metastasis and Interaction of Tumor Cells and Lymphatic Endothelial Cells

LIU Ying-lei，XIE Jing-yan   

  1. Department of Obstetrics and Gynecology，the Affiliated Nanjing Hospital of Nanjing Medical University，Nanjing 210006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-02-15 Online:2014-02-15
  • Contact: XIE Jing-yan

PDF (PC)

5153

摘要： 肿瘤淋巴转移是医学界亟待解决的难题之一，以往研究多集中在肿瘤细胞本身，难以全面阐释淋巴转移的发病机制。近年研究发现，肿瘤细胞能与肿瘤微环境中其他细胞发生交互作用，淋巴管内皮细胞（lymphatic endothelial cell，LEC）是肿瘤微环境中的重要一员，与肿瘤的淋巴转移密切相关。鉴于此，深入研究肿瘤细胞与LEC的交互作用可能会为肿瘤淋巴转移的病因研究及传统抗癌治疗带来新的曙光。

关键词: 淋巴细胞, 肿瘤浸润, 内皮细胞, 内皮生长因子, 淋巴管生成, 淋巴转移

Abstract: Tumor lymphatic metastasis is one of the most sophisticated medical problems with undetermined etiology and high mortality，demanding prompt solutions. Although various hypotheses have been introduced previously and researches have focused on the tumor cells themselves，none of which can fully elucidate the pathogenesis of lymphatic metastasis. Recent researches have shown the interaction between tumor cells and other cells in the tumor microenvironment. Lymphatic endothelial cell （LEC） is an important one in the tumor microenvironment，closely relating with tumor lymphatic metastasis. Therefore，further study on interaction of LEC and tumor cells may bring a new dawn for the etiology of lymphatic metastasis as well as traditional anti-cancer treatment.

Key words: Lymphocytes, tumor-infiltrating, Endothelial cells, Endothelial growth factors, Lymphangiogenesis, Lymphatic metastasis