国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (2): 142-145.

• 综述 • 上一篇    下一篇

miRNA与卵巢癌的侵袭转移机制研究进展

吴香，柳露   

  1. 650051 昆明市延安医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-04-15 发布日期:2014-04-15

Mechanisms of miRNA in Invasion and Metastasis of Ovarian Cancer

WU Xiang，LIU Lu   

  1. Department of Obstetrics and Gynecology，Yan′an Hospital of Kunming，Kunming 650051，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-04-15 Online:2014-04-15

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摘要： 国内外学者对发病隐匿、进展快、预后差、复发率高的卵巢恶性肿瘤做了大量研究，但其早期诊断率及生存率未见上升、死亡率未见降低，且死亡率居妇科恶性肿瘤首位，成为严重威胁妇女生命健康的主要肿瘤。微小RNA（miRNA）为新发现的非编码内源性小分子RNA，发现其调节人类近30%的基因表达，生物学特性为高度保守性、时序表达特异性和组织表达特异性，在卵巢癌中扮演重要角色。研究发现，miRNA参与卵巢癌肿瘤细胞的发生、侵袭转移过程，与卵巢癌的预后密切相关。综述miRNA与卵巢癌侵袭转移关系的最新研究进展。

关键词: 微RNAs, 卵巢肿瘤, 肿瘤侵润, 预后

Abstract: Domestic and foreign scholars on the occult onset，rapid progression，poor prognosis，recurrence rate of malignant ovarian tumor did a lot of researches，but the rate of early diagnosis and survival rate did not increase，without reducing mortality，and the first mortality in gynecological malignant tumor，ovarian cancer become the main cancer seriously threatens women health life. miRNA is a non-coding endogenous small RNA newly found， regulating the expression of nearly 30% genes of human，its biological characteristics of specific expression in tissue，highly conservative and temporal expression play an important role in ovarian cancer. The study found that miRNA involved in the process of invasion and metastasis of ovarian cancer cells，but also closely related to the prognosis in patients with ovarian cancer. In order to understand the mechanism of invasion and metastasis of malignant ovarian cancer，this review summarizes the new progress of miRNA and ovarian cancer.

Key words: MicroRNAs, Ovarian neoplasms, Neoplasm invasiveness, Prognosis