国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (2): 146-149.

• 综述 • 上一篇    下一篇

激素替代疗法与乳腺癌关系的研究进展

孙芳芳，史惠蓉   

  1. 450052 郑州大学第一附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-04-15 发布日期:2014-04-15
  • 通讯作者: 史惠蓉

Progress of Hormone Replacement Therapy and Breast Cancer

SUN Fang-fang，SHI Hui-rong   

  1. Department of Obstetrics and Gynecology，the First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-04-15 Online:2014-04-15
  • Contact: SHI Hui-rong

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摘要： 激素替代疗法（hormone replacement therapy，HRT）在改善妇女绝经症状、预防骨质疏松、减少骨折发生等方面的作用已成共识，但其对乳腺癌、心脑血管疾病及其他慢性疾病的影响尚存在争议。单用雌激素可能不增加乳腺癌风险，雌孕激素联合应用可能增加乳腺癌风险。不同乳腺疾病患者应用HRT后乳腺癌发病风险不同，中国女性HRT与乳腺癌的关系尚未完全明确。在近绝经期有适应证的妇女中应用HRT的收益大于风险，且HRT的种类与使用途径对乳腺癌的发病风险可能不同。综述HRT与乳腺癌的关系以及HRT在不同乳腺疾病患者中的应用。

关键词: 激素替代疗法, 乳腺肿瘤, 绝经期, 乳腺疾病, 治疗

Abstract: Hormone replacement therapy （HRT） can alleviate postmenopausal women′ menopausal symptoms，prevent osteoporosis and reduce fractures with a consensus，but its influence on breast cancer，cardiovascular disease and other chronic diseases is still controversial. Using estrogen alone may not increase the risk of breast cancer，while combining estrogen with progesterone may increase breast cancer′s risk. Different breast disease patients may suffer different risks of breast cancer after HRT，the relationship between Chinese women HRT and breast cancer are uncertain. Benefits exceed risks when applying HRT on women who have indications close to post menopause，different types and occupy pathways of HRT may result in different breast cancer risks. Summarize the relationship between HRT and breast cancer as well as HRT applications in patients with different breast disease.

Key words: Hormone replacement therapy, Breast neoplasms, Menopause, Breast diseases, Therapy