关键词: 宫颈肿瘤, 肿瘤转移, 淋巴转移, 淋巴细胞, 肿瘤浸润, 妇科外科手术

Abstract: Parametrial involvement is one of the most important prognostic factors of cervical cancer. Parametrial involvement is defined as either malignant cell in the parametrium or tumor emboli within lymphvascular channels or lymph nodes. The factors associated with parametrial involvement of early cervical cancer are age，stage，grade，tumor size，invasion depth，pelvic lymph node metastases，lymphvascular invasion（LVSI），uterine involvement，vaginal involvement，the preoperative serum of squamous cell carcinoma and ovarian metastasis. It is generally believed that the most important factors associated with parametrial involvement of early cervical cancer are tumor size，invasion depth，pelvic lymph node metastases，LVSI. The researchers have proposed the criteria of the low risk for parametrial involvement include tumor size≤2 cm，invasion＜5 mm or ＜10 mm，negative lymph nodes and negative lymphvascular invasion. Patients at low risk could be considered for less radical surgery such as modified radical hysterectomy or simple hysterectomy or trachelectomy with pelvic lymphadenectomy.

Key words: Uterine cervical neoplasms, Neoplasm metastasis, Lymphatic metastasis, Lymphocytes, tumor-infiltrating, Gynecologic surgical procedures