国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (4): 370-373.

• 论著 • 上一篇    下一篇

乳腺癌转移抑制基因1和核因子相关κB结合蛋白50在宫颈癌变中的表达

毛莉，杨永秀   

  1. 730000 兰州大学第一临床医学院（毛莉）；兰州大学第一医院妇产科（杨永秀）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 杨永秀

Expression and Clinical Significance of BRMS1 and NF-κB in Cervical Carcinogenesis

MAO Li，YANG Yong-xiu   

  1. The First Clinical Medicine College of Lanzhou University，Lanzhou 730000，China（MAO Li）；Department of Obstetrics and Gynecology，the First Hospital of Lanzhou University，Lanzhou 730000，China（YANG Yong-xiu）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: YANG Yong-xiu

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摘要： 目的：探讨乳腺癌转移抑制基因1（BRMS1）、核因子相关κB结合蛋白50（ NF-κB p50 ）在宫颈癌变过程中的表达及其临床意义。方法：采用免疫组化（Super Sensitive TM IHC）法分别检测慢性宫颈炎组织、CINⅠ组织、CINⅡ～Ⅲ组织和宫颈癌组织中BRMS1、NF-κB p50 的表达，分析两者的表达水平与宫颈癌临床病理特征的关系。结果：①宫颈癌、CINⅡ～Ⅲ及CINⅠ组组织中BRMS1蛋白的表达低于慢性宫颈炎组，差异有统计学意义（均P＜0.05），且BRMS1蛋白在ⅡB～Ⅳ期、浸润深度＞1/2、有淋巴结转移者中表达降低甚至缺失（均P＜0.05）。②NF-κB p50蛋白在宫颈癌组、CINⅠ和CINⅡ～Ⅲ组中的阳性表达率高于慢性宫颈炎组（均P＜0.05），且在瘤体直径≥4 cm、低分化癌、浸润深度＞1/2、有淋巴结转移者中NF-κB p50蛋白表达升高，差异有统计学意义（均P＜0.05）。③宫颈癌中BRMS1与NF-κB p50蛋白表达水平呈负相关（rs=0.426，P＜0.001）。结论：宫颈癌中BRMS1蛋白与NF-κB蛋白的阳性表达呈负相关，BRMS1蛋白阳性表达逐渐下降、甚至缺失，而NF-κB蛋白阳性表达逐渐升高，与癌细胞的发展、浸润转移密切相关。

关键词: 宫颈肿瘤, 癌, 基因, 肿瘤抑制, 基因, NF-κB, 免疫组织化学, 乳腺癌转移抑制基因1

Abstract: Objective：To study the protein expression and clinical significance of breast cancer metastasis suppressor l（BRMS1） and nuclear factor kappa B（NF-κB p50） in cervical carcinogenesis. Methods：The immunohistochemical method（Super Sensitive TM IHC）was used to determine expressions of BRMS1 and NF-κB p50 were in chronic cervicitis tissues，CINⅠ tissues，CINⅡ-Ⅲ tissues and cervical carcinoma tissues. The clinical significance was analyzed with histopalthological records. Results：① The positive rates of BRMS1 in cervical carcinoma ,CINⅠand CINⅡ-Ⅲ tissues were much lower than that in chronic cervicitis tissues, the differences were significant（all P<0.05），moreover the positive expressions were much lower or absent in cervical cancer tissues with ⅡB-Ⅳ stage，depth of invasion>1/2 and with lymph node metastasis, the differences were significant（all P＜0.05）. ②The positive rates of NF-κB p50 in cervical carcinoma，CINⅠand CIN Ⅱ-Ⅲ tissues were much higher than that in chronic cervicitis tissues（all P<0.05），moreover the positive expressions were much higher in cervical cancer tissues with tumor size≥4 cm，poor differentiation，depth of invasion>1/2 and with lymph node metastasis, the differences were significant（all P＜0.05）. ③The expression level of BRMS1 was negatively correlated with that of NF-κB p50 in cervical carcinoma（rs= 0.426，P＜0.001）. Conclusions：It is closely related to cancer cell invasion and metastasis that the expression of BRMS1 decreased significantly，while the expression of NF-κB conversely increased. In addition，BRMS1 may inhibit NF-κB expression in invasion and metastasis of cervical cancer.

Key words: Uterine cervical neoplasms, Carcinoma, Genes, tumor suppressor, Genes, NF-kappa B, Breast cancer metastasis suppressor 1